Described herein are nanostraw well insert apparatuses (e.g., devices and systems) that include nanotubes extending through and out of a membrane so that a material can pass through the membrane from a fluid reservoir depot and into a cell grown onto the nanotubes when electrical energy (e.g., electroporation energy) is applied. In particular, the device, systems and methods described herein may be adapted for cell growth viability and transfection efficiency (e.g., >70%). These apparatuses may be readily integratable into cell culturing processes for improved transfection efficiency, intracellular transport, and cell viability.

A method includes: depositing whole blood into at least one separator tube; subjecting the at least one separator tube to a first centrifugal force to cause a combination of the first centrifugal force and separator gel within each separator tube of the at least one separator tube to separate plasma of the whole blood from red and white blood cells of the whole blood within the at least one separator tube, wherein the plasma includes α2M molecules; transferring one or more portions of the plasma from within the at least one separator tube and into at least one isolator; and subjecting the at least one isolator to a second centrifugal force to cause a combination of the second centrifugal force and a filter within each isolator of the at least one isolator to isolate the α2M molecules from other components of the plasma within the at least one isolator.

A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips.

A method for the contact metering of liquids having the following steps: a first liquid is introduced into at least one elongate hollow body, some of the first liquid contained in the elongate hollow body is pressed out of the lower end of the elongate hollow body as a contacting volume such that the contacting volume forms a drop suspended from the lower end of the elongate hollow body, at least some of the drop is immersed in a second liquid in a target vessel and the defined metering volume consisting of the contacting volume and a residual volume contained in the elongate hollow body is dispensed into the second liquid.

Broadly speaking, embodiments of the present techniques provide a modular sample processing device which allows a user to perform any number of biological processes within a single device, in the order the user requires. The device is customisable—a user may select two or more modules and connect them in series to form the device in which the biological processing takes place. Advantageously, this may enable a user to perform multiple processes within a single device and potentially outside of a laboratory (e.g. during field work) or outside of sterile/aseptic environments. Furthermore, the device is a hand-held device, which means the device is compact and easy to transport and use for field work.

According to an embodiment of the disclosure, a vial cap is configured for sealing attachment to a tube set and to a vial having a hollow interior configured for receiving and storing a liquid sample. The vial cap may comprise an axially extending cylindrical wall and a radially extending cap top disposed within the cylindrical wall, wherein the cap top has an upper surface and a lower surface. The vial cap may include at least two exterior tubes extending upwardly from the upper surface of the cap top, wherein each exterior tube defines a passageway configured to communicate with the tube set. The vial cap may further include at least two interior tubular structures extending downwardly from the lower surface of the cap top, wherein the at least two interior tubular structures each define a passageway configured to communicate with one of the exterior tubes and the hollow interior.

A cell purification module, configured to purify multiple cells from a fluid sample is provided. The cell purification module includes a hollow column, multiple hollow fiber membranes, at least one first magnetic component, a fluid sample inlet end, and a fluid sample outlet end. The hollow column has a first opening, a second opening, and an accommodating space connecting the first opening and the second opening. The hollow fiber membranes are disposed in the accommodating space and each hollow fiber membrane has multiple pores. The first magnetic component is disposed at a periphery of the hollow column. The fluid sample inlet end and the fluid sample outlet end are respectively disposed at two ends of the hollow column. The hollow fiber membranes extend in an axial direction of the hollow column, and are arranged in a radial direction of the hollow column. A cell purification system is also provided.

A fluid transfer device includes a syringe barrel having a chamber, a first plunger slidably movable inside the chamber, and a second plunger slidably movable inside the chamber. The distal end portion of the first plunger is engageable with the proximal end portion of the second plunger such that when the distal end portion of the first plunger and the proximal end portion of the second plunger are engaged, the second plunger is movable by the first plunger. A check valve may be incorporated into the distal end portion of the second plunger to allow a fluid to pass therethrough in a direction towards the proximal end portion of the second plunger and prevent a fluid to pass therethrough in a reverse direction. A fluid transfer assembly and a sampling method are also described.

Systems and methods for detecting the presence of a target nucleic acid in a sample via a recombinase polymerase amplification (RPA) reaction followed by a FEN1 cleavage detection reaction are disclosed. One aspect of the present disclosure relates to systems involving a sample collection device for collecting a sample and performing an RPA reaction on the sample, followed by the detection of the amplified product via a two-step FEN1 cleavage detection reaction which generates a fluorescent signal indicative of the presence of amplified product.

The present invention provides a detection device comprises a testing element and a transparent area, wherein the testing element comprises a detection area which is configured to detect a presence of an analyte in a liquid sample; the transparent area is configured to read the test result on the detection area through the transparent area; a part of the transparent area contacts a part of the detection area, or the detection area and the transparent area are arranged in one sealed space, thus to make the air in the sealed space not exchange with the air outside the sealed space; the scheme can reduce the mist to ensure the test result is displayed clearly.