Devices and methods for providing and dispensing opposables onto slides are provided in which magazines loaded with opposables include retention arms to reduce movement of the opposables during shipment and processing and to reduce or eliminate contamination.

A test tube holding assembly or test tube rack includes at least two test tube holders, where each test tube holder in turn defines a central longitudinal axis, two storage zones, and includes a connecting member. The connecting members permit coupling of the two test tube holders and rotation of the two coupled test tube holders about an axis parallel to the longitudinal axis of at least one of the test tube holders. The test tube holders are also positionable in multiple orientations, where each orientation at least partially determines which of the two storage zones are available to receive a test tube therein.

A centrifuge tube holding assembly includes a body having a front side, a back side, a top edge, a bottom edge, a first lateral edge and a second lateral edge. The top edge has a plurality of apertures extending downwardly therein and each of the apertures may be used for removably receiving an ultracentrifuge tube. The front wall has an opening therein for viewing an open space positioned below the top edge. A panel is positioned over the opening. The panel is transparent to allow viewing through the panel.

The panel has measurement indicia thereon configured to be positioned to be alignable with the ultracentrifuge tube.

An assay plate is provided. The assay plate has a body with a plurality of reservoirs formed therein. The reservoirs are shaped and aligned in the body in an orientation to induce drainage of fluids contained therein in a desired direction. A plate array and a funnel array forming an assembly for pooling of samples contained in the assay plate is also provided.

Fluidic systems and reagent carriers suitable for storing reagents in a desirable manner are generally provided. In some embodiments, a reagent carrier stores a liquid film comprising a solid reagent and/or stores different reagents in different locations. In some embodiments, a fluidic system comprises a reagent carrier constrained such that it comprises an elongated axis positioned within 30° of a vertical axis of the fluidic reservoir.

The present invention relates to a microfluidic device (1) for cultivating cells, in particular for generating brain organoids, comprising at least two fluid channels (2) positioned essentially opposite to each other and a main chamber (3) located between the fluid channels (2), wherein the main chamber (3) comprises at least one preferably sealable access opening, and each of the at least two fluid channels (2) is fluidly connected to the main chamber (3) at at least one point of contact (4), wherein a slotted structure (5) is provided at each point of contact (4) separating the main chamber (3) from the respective fluid channel (2), wherein the slotted structure (5) is permeable to a liquid.

The present invention is in the field of an all-in-one microchamber for 3D muscular tissues, wherein at least one 3D microenvironment is present, a method of producing said device using silicon-based technology, and a use of said device in various applications, typically a biological cell experiment, such as a cell or organ-on-a-chip experiment, and lab-on-a-chip experiment, and use of the device as a micro-reactor.

A reagent container for a tissue processor includes a first body defining a cavity configured to contain reagent; and a second body attached to the first body, wherein the second body defines a reagent passage, a cistern room and an reagent port, the reagent passage is in communication with the cavity, the cistern room is provided between the reagent passage and the reagent port and in communication with the reagent passage and the reagent port; in a flowing direction towards the reagent port, the cistern room has a larger section area than a section area of the reagent passage. The reagent coming out of the reagent passage will significantly slow down in a short time and will not spill out of the reagent container through the reagent port, thereby improving anti-spilling performance of the reagent container during transportation or operation of the reagent container.

A container assembly prevents a situation in which an aqueous liquid layer is contaminated by a component of another aqueous liquid layer even when stored for a long time. A container assembly has a structure in which an adsorption container, a reaction container, a washing container, and an elution container are joined to form a flow channel through which the target nucleic acid is moved. The washing container may include a first washing container, a second washing container, and a third washing container. The washing containerseal-tightly holds a first washing liquid, a second washing liquid, a third washing liquid, a first oil, a second oil, a third oil, and a fourth oil, the first oil, the second oil, the third oil, and the fourth oil being immiscible with the first washing liquid, the second washing liquid, and the third washing liquid. The first washing liquid, the second washing liquid, and the third washing liquid are liquids with which a magnetic bead on which a nucleic acid is adsorbed is washed. The elution container seal-tightly holds an eluent and a fluid that is immiscible with the eluent. The eluent is a liquid with which the target nucleic acid is eluted from the magnetic bead.

A microfluidic apparatus, systems and methods for microfluidic crystallization based on gradient mixing. In one embodiment, the apparatus includes (a) a first layer, (b) a plurality of first channels and a plurality of vacuum chambers both arranged in the first layer, where the plurality of vacuum chambers are each coupled to at least one of the first channels, (c) a membrane having first and second surfaces, where the first surface of the membrane is coupled to the first layer, (d) a second layer coupled to the second surface of the membrane, (e) a plurality of wells and a plurality of second channels both arranged in the second layer, where the wells are each coupled to at least one of the plurality of second channels and (f) a plurality of barrier walls each disposed in the plurality of second channels and arranged opposite to one of the plurality of vacuum chambers.