Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.

The present invention relates to a platelet testing device using blockage phenomenon, comprising: a sample chamber containing blood sample; a microfluidic tube which is in fluid communication with the sample chamber and through which the blood sample flows; and a microbead packing arranged on a flow path of the blood sample of the microfluidic tube; wherein the microbead packing comprises: a packing pipe which constitutes a part of the flow path of the blood sample; and a plurality of microbeads contained in the packing pipe and arranged to be in close contact with each other so as to form voids between the microbeads, whereby function of the platelet is tested by blockage phenomenon of the voids due to the platelet in the blood sample which flows through the microfluidic tube from the sample chamber according to the present invention.

The current invention relates to the method and apparatus to magnetically separate biological entities with magnetic labels from a fluid sample. The claimed magnetic separation device removes biological entities with magnetic labels from its fluidic solution by using a soft-magnetic center pole with two soft-magnetic side poles. The claimed device further includes processes to dissociate entities conglomerate after magnetic separation.

A sensing device includes a sample loading chamber configured to receive a sample, a detection antibody drying or lyophilization chamber configured to receive a first portion of the sample, one or more substrate drying or lyophilization chambers configured to receive a second portion of the sample, and one or more reaction chambers connected to the detection antibody drying or lyophilization chamber and the one or more substrate drying or lyophilization chambers. The detection antibody drying or lyophilization chamber and one or more substrate drying or lyophilization chambers are placed in parallel between the sample loading chamber and the one or more reaction chambers.

A blood clotting time measurement cartridge includes: an inlet on one end of a measurement flow channel and through which blood is introduced; a communication opening on the other end of the measurement flow channel and through which air suction or air pressure application or the blood introduced from the inlet is performed; a moving body arranged in the measurement flow channel moves; a clotting accelerator applied on at least one of a flow channel wall surface, which defines the measurement flow channel, and the moving body; and a detection area through which light is transmitted to a predetermined part in the measurement flow channel, and where it is possible to detect with light whether there is the moving body or the blood making a reciprocating motion in the measurement flow channel in association with air suction or air pressure application or the blood from the communication opening.

A test container includes a container main body including a first-accommodation-portion, a second-accommodation-portion, and a third-accommodation-portion each accommodating a liquid and internally provided, a first flow path connecting the first-accommodation-portion and the second-accommodation-portion to each other at respective upper end positions thereof and internally provided, and a second flow path connecting the second-accommodation-portion and the third-accommodation-portion to each other at respective upper end positions thereof and internally provided, in which at least a portion forming an upper wall surface of the second-accommodation-portion has flexibility to be deformable inwards of the second-accommodation-portion; and a liquid return prevention structure which prevents a backflow of the liquid to the first-accommodation-portion, when the liquid accommodated in the second-accommodation-portion is fed to the third-accommodation-portion via the second flow path due to deformation of the portion forming the upper wall surface of the second-accommodation-portion inwards of the second-accommodation-portion.

[Problem] To ensure that a fluid is prevented from overflowing from a well and exposing the user to a biohazard. [Solution] A cartridge for use in measuring a component to be measured contained in a fluid includes a recessed well, formed for storing the fluid, the well including: a lower barrel portion that defines a lower space having a closed bottom; and an upper barrel portion that is formed above the lower barrel portion and defines an upper space having an opening on the top end, wherein a step portion is formed between the lower barrel portion and the upper barrel portion, the step portion being formed on an inner wall surface of the well and defining a step that continuously connects the inner wall surface of the lower barrel portion and the inner wall surface of the upper barrel portion.

Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.

A method herein to isolate exosomes includes providing a microfluidic device having a spiral-shaped channel in fluid communication with two inlet ports and at least two outlet ports. One of the two inlet ports is proximal to an inner wall of the spiral-shaped channel and the other is proximal to an outer wall thereof. At least one of the outlet ports is in fluid communication with a container for storing isolated exosomes. A blood sample and sheath fluid are introduced into the inlet ports proximal to the outer and inner walls, respectively, to form a diluted sample in the spiral-shaped channel and driven through for exosomes recovery in the container. The spiral-shaped channel in fluid communication with a first outlet port includes a first outlet channel connecting the spiral-shaped channel to the first outlet port and is longer than other outlet channels respectively connecting the spiral-shaped channel to the other outlet ports. A method of identifying diabetes mellitus is also disclosed herein.

The present disclosure provides a substrate for driving droplets, a manufacturing method thereof, and a microfluidic device. The substrate includes a first base substrate a plurality of leads on the first base substrate a plurality of driving electrodes on a side of the plurality of leads away from the first base substrate and a shielding electrode on the side of the plurality of leads away from the first base substrate and grounded. Each of the plurality of leads is electrically connected to at least one of the plurality of driving electrodes, an orthographic projection of the shielding electrode on the first base substrate and an orthographic projection of at least one of the plurality of leads on the first base substrate at least partially overlap, and the shielding electrode is electrically insulated from the plurality of driving electrodes.