A cell evaluation device includes: a porous membrane having a first main face and a second main face; a first passage having a first passage portion facing a first area on which cells are placed in the first main face of the porous membrane; a second passage having a second passage portion facing a second area in the second main face of the porous membrane, the second area being positioned backside of the first area; and a first electrode provided in the first passage portion and a second electrode provided in the second passage portion, the first electrode and the second electrode being positioned across the first area and the second area. In the cell evaluation device, tight junctions are formed among the cells by cell cultivation. With the cell evaluation device, any increase in the electric resistance occurring due to the formation of the tight junctions can be easily measured.

A cell chip includes first, second and third elements, a dye dialysis layer, a micro-channel structure and washing solution inlet and outlet. The first element has a first hole and second holes at opposite sides of the first hole. The second element has a third hole corresponding to the first hole and fourth holes corresponding to the second holes. The dye dialysis layer is inserted between the first element and the second element and has a cell-assembly region corresponding to the first and third holes. The micro-channel structure is disposed below the cell-assembly region and between the second and the third elements. The washing solution inlet and outlet are communicatively connected to the micro-channel structure. The washing solution inlet includes the second hole and a corresponding fourth hole. A washing solution flows in the micro-channel structure through the washing solution inlet and outlet.

A biological chip, a manufacturing method thereof, an operation method thereof, and a biological detection system are provided. The biological chip includes a base substrate and a plurality of working units. The plurality of the working units are arranged on the base substrate; each of the working units includes a working element configured to be in contact with a target substance; and the working element includes a metal electrode and an electric-field-controllable surface modification layer on a surface of the metal electrode.

A liquid droplet manipulation system has a substrate with at least one electrode array and a central control unit for controlling selection of individual electrodes of the electrode array and for providing the electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. A working film is placed on top of the electrodes for manipulating samples in liquid droplets with the electrode array. At least one selected individual electrode of the electrode array is configured to be penetrated by light of an optical detection system for the optical inspection or analysis of samples in liquid droplets that are located on the working film. Also disclosed is working film that is to be placed on the electrode array and a cartridge that includes such a working film for manipulating samples in liquid droplets.

A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap.

A flow path device includes a first portion, and a second portion. The first portion includes a resin first body and a first reinforcement. In the first body, a first connector connects a first outer portion and a first joint having a groove pattern defining a first flow path.

The first reinforcement is between and bonded to the first outer portion and the first joint, and includes first protrusions protruding from the first body and including two specific-shaped portions. The second portion includes a resin second body and a second reinforcement. In the second body, a second connector connects a second outer portion and a second joint, and through-holes connect to the first flow path. The second reinforcement is between and bonded to the second outer portion and the second joint, and includes second protrusions protruding from the second body and including two specific-shaped portions.

Disclosed are a detection chip and a manufacturing method therefor, and a reaction system. The detection chip includes: a first substrate (11); a microcavity defining layer (12), which is located on the first substrate (11) and defines a plurality of micro-reaction chambers (120); and a shading structure layer (13), which is located on the first substrate (11) and provided among the plurality of micro-reaction chambers (120). In practical application, the number of target molecules in a reaction system solution in each micro-reaction chamber (120) can be determined by collecting a fluorescence image; and the detection chip is provided with the shading structure layer (13), and the shading structure layer (13) is located on the first substrate (11) and provided among the plurality of micro-reaction chambers (120).

A structure is manufactured by forming a mask that has an opening pattern on a surface of a substrate, etching the surface of the substrate with the mask to form a recessed portion corresponding to the opening pattern of the mask, forming a thin film including aluminum on a bottom surface of the recessed portion in a state where the mask remains, treating the thin film including aluminum with hot water to change the thin film into a fine recessed and projected layer including alumina hydrate smaller than the recessed portion, etching the bottom surface of the recessed portion, on which the fine recessed and projected layer is formed, in a state where the mask remains to form a fine recessed and projected structure on the bottom surface of the recessed portion, and thereafter removing the mask and the fine recessed and projected structure, which remains after the etching step.

The present disclosure relates to a micro-channel device. The micro-channel device may include a micro-channel structure and a semiconductor junction. The micro-channel structure may include a base layer, a plurality of rails distributed on the base layer at intervals, and a cover layer comprising a plurality of columns. The cover layer and the base layer are configured to form a plurality of micro-channels. The semiconductor junction may include a P-type semiconductor layer, an intrinsic semiconductor layer and a N-type semiconductor layer stacked in a first direction.

An electrowetting-on-dielectric (EWOD) microfluidic device comprises at least one integrated electrochemical sensor, the electrochemical sensor comprising: a reference electrode; a sensing electrode; and an analyte-selective layer positioned over the sensing electrode. In some embodiments, the electrochemical sensor measures a concentration of an analyte in a fluid sample exposed to the electrochemical sensor based on a potential difference between the reference electrode and the sensing electrode. The first analyte and the second analyte can be selected from a group consisting of K.sup.+, Na.sup.+, Ca.sup.2+, Cl.sup.−, HCO.sub.3.sup.−, Mg.sup.2+, H.sup.+, Ba.sup.2+, Pb.sup.2+, Cu.sup.2+, I.sup.−, NH4.sup.+, (SO4).sup.2−.