A tight connection device for the aseptic transfer of a biopharmaceutical product includes: a stationary temporary clamping means keeping the container hermetically clamped against the chamber; a stationary unlocking means capable of switching the container from an initial locked position to an intermediate unlocked position; a stationary locking means; and an annular functional crown capable of being rotated to actuate the stationary unlocking means and the stationary locking means of the container. The stationary unlocking means and the stationary locking means are mechanically linked to the annular functional crown and arranged such that the rotation of the annular functional crown and the end locked position. The device further includes stationary immobilising/release means capable of allowing and preventing the annular functional crown to rotate.

A channel assembly is disclosed, which may comprise a microfluidic channel. Methods of manufacture are also disclosed as are detectors and detector components which may comprise such a channel assembly. An example is a detection apparatus comprising: a detector for detecting a substance of interest; and a pneumatic system comprising a microfluidic channel assembly comprising a first microfluidic channel for dispensing vapour to the detector, wherein the first microfluidic channel comprises a groove in a surface of a polymer body and a wall of the first channel is provided by a film bonded to the surface of the body over the groove.

The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow. The platform enables the concurrent running of multiple detection assay techniques such as lateral flow immunoassays (LFI), Isothermal molecular assays (i.e., Recombinase Polymerase Amplification, or RPA) and/or paper-based chemical assays (i.e., M8, pH paper) from a single wet or dry sample with minimal sample processing. The PDP reduces soldier overburden by decreasing size weight, and power (SWaP) as well as training time, electronic burden, while providing a flexible, customizable assay platform that can be rapidly produced, assembled, sustained, and when contaminated, easily to dispose of.

Pipette assembly comprising a pipette device, a pipette tip, and an expanding mandrel collet coupling device coupling the tip to the pipette device, the coupling device comprising: circumferentially spaced apart segments, an annular base disposed below the segments and comprising a distal portion, an elastomeric element circumscribing the distal portion, and upwardly extending circumferentially spaced apart arms attached at first ends to the annular base and having upper free ends each supporting a different one of the segments configured to expand between a first and a second greater circumference for engaging a first interior working surface of the tip in concurrence with the elastomeric element sealing against a second interior working surface below the first surface and in concurrence with an abutment between a disk exteriorly disposed about a medial portion of the arms and a stepped interior shoulder of the tip disposed between the first and second working surfaces.

Provided herein are devices, kits, systems, and methods for collecting samples for analytical analysis and the safe disposal of sample collection devices after their use. The devices, kits, systems, and methods find use, for example, for disposing of biohazard materials by users in settings that may not be equipped with the professional biohazard disposal systems of laboratories, hospitals, and medical clinics.

Provided herein are examples of mRNA treatment nanoparticles and methods of using them to treat a patient. An mRNA treatment nanoparticle may include one or more mRNAs encoding a tumor-specific antigen and an immunomodulatory agent; and a delivery vehicle molecule encapsulating the one or more mRNAs.

In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.

A fluidic component including a fluidic circuit having at least one fluidic access through which a fluid is intended to pass, an actuator capable of expanding, a deformable membrane that can be actuated by the expansion of the actuator, sealing device for sealing off the fluidic access and including at least a body made of a meltable compound configured to adopt two states: a solid first state, a molten second state obtained under the effect of an increase in temperature, the body of meltable compound being designed to be moved in the molten state, by the expansion of the actuator, between a standby position and a distinct sealing-off position for sealing off the fluidic access.

A fluidic component intended to be associated with a heating module and wherein there is created a fluidic circuit which includes an inlet channel and an outlet channel, the fluidic component including a fluidic valve mechanism including: a fluidtight reservoir intended to be filled with a volume of gas capable of expanding, a deformable membrane closing the reservoir in a fluidtight manner, the membrane being able to deform by expansion of the volume of gas, between a first position wherein it forms a passage between the inlet channel and the outlet channel so as to allow a fluid to pass, and a second position wherein it obstructs the passage.

The present invention is directed to a method for sorting biological objects including the steps of providing a magnetic device that includes a conduit or channel having upstream and downstream sections and a magnetic means for generating first and second magnetic fields in the upstream and downstream sections, respectively; flowing a sample fluid that includes magnetically labeled biological objects and unlabeled biological objects through the upstream section to magnetically saturate the magnetically labeled biological objects by the first magnetic field; and flowing the sample fluid from the upstream section continuously to the downstream section to collect the magnetically labeled biological objects on a wall of the downstream section by the second magnetic field, wherein the first magnetic field in the upstream section has a higher average field strength than the second magnetic field in the downstream section.