Embodiments of fiber substrate-based fluidic device and methods of manufacturing the same are described herein. In one example, a method of manufacturing a fiber substrate-based fluidic device comprises bonding a hydrophobic film that is substantially transparent to a laser beam (e.g., a film that transmits at least 80% of the incident radiant power of the laser beam) to a hydrophilic substrate and ablating the hydrophilic substrate with the laser beam without ablating the hydrophobic film to form one or more fluidly sealed channels in the hydrophilic substrate.

A sample testing chip includes a first layer formed of a porous hydrophilic material. One or more hydrophobic barriers are located in the first layer to define one or more testing areas configured to receive a volume of a sample and one or more auxiliary areas. The one or more testing areas and the one or more auxiliary areas are separated from one another by the hydrophobic barrier and are not fluidically connected. Methods of fabrication and use of the sample testing chip are also disclosed.

The present invention provides a device for detecting an analyte in a sample, including a chamber for receiving a testing element, where the testing element has a first position and a second position in the chamber; the testing element is not in contact with a fluid sample when the testing element is located in the first position, and the testing element is in contact with a fluid sample when the testing element is located in the second position.

There is provided a microfluidic device comprising a disposable microfluidic test card for capillary driven liquid sample processing, the disposable microfluidic test card comprising a sample inlet, arranged for receiving liquid sample at the microfluidic test card, at least one test reagent reservoir arranged for holding of test reagent, an analysis zone for analysis of liquid sample components, and a microfluidic sample processing zone arranged in fluidic connection with the sample inlet and the at least one test reagent reservoir, for receiving of liquid sample and test reagent, respectively, therefrom, the microfluidic sample processing zone being further arranged for metering and providing a predetermined volume of liquid sample, mixing or contacting of the predetermined volume of liquid sample with test reagent, allowing processing of liquid sample mixed or contacted with test reagent, and fluidic connection with the analysis zone for providing processed liquid sample to the analysis zone, wherein the analysis zone is arranged for presenting processed liquid sample to a reader.

A microfluidic diagnostic device comprises a base and at least one switch coupled to a portion of the base, the switch comprising a flap that is pivotable with respect to the base from a first position spaced away from the base a first distance to a second position where the flap is spaced away from the base a second distance. Both the base and the switch comprise one or more channels that permit passive transportation of an aqueous solution. The switch may be formed by bending or deforming a strip to cause the flap to be in the first position when there is less than a predetermined amount of fluid within the channel of switch. When a predetermined amount of fluid is in the channel of the switch, the flap pivots to the second position, which may be achieved through power from gravity, capillarity, and/or inherent elastic energy.

The present invention relates to a device and a method for qualitative and quantitative analysis of heavy metals and more particularly provides a device and a method for qualitative and quantitative analysis of heavy metals utilizing a rotary disc system.

Lateral flow devices, methods and kits for performing lateral flow assays are provided.

This present disclosure provides devices, systems, and methods for performing point-of-care analysis of a target analyte in a biological fluid via a binding assay. The present disclosure includes a cartridge for collecting the target analyte contained in a fluid sample and performing an assay. The cartridge includes an assay stack having a first separation layer, a second separation layer, and a detection membrane. The cartridge also includes a plurality of first complexes comprising a capture molecule and a magnetic bead and a plurality of second complexes comprising a detection molecule and a detection label. Further, the detection membrane includes a substrate that interacts with the detection label to elicit a quantifiable response in the presence of the target analyte. The quantifiable response corresponds to an amount of detection antibody present in the detection membrane, and the amount of detection antibody present corresponds to an amount of the target analyte present.

A multilayer microfluidic device comprising: an inlet section comprising an inlet port and configured to transport and access the sample to a flat, laterally extending filtration membrane; a metering section, comprising an extraction chamber configured to receive an extracted body fluid from the filtration membrane and arranged in fluid communication with a metering channel; and an outlet section comprising a capillary means for collection of the metered volume of body fluid, wherein a roof of the extraction chamber is defined by a flat lower surface of the filtration membrane, and a floor of the extraction chamber is continuous with a floor of the metering channel and extends at an acute angle from the lower surface of the filtration membrane, and wherein the floor of the extraction chamber is inclined with respect to the floor of the metering channel to create a slope.

A microfluidic device configured to sample, meter and collect a metered volume of body fluid for analysis by means of capillary transport, wherein the device comprises: an inlet section for receiving a sample of body fluid, the inlet section comprising an inlet port and a channel system; a filtration membrane configured to separate plasma from blood, wherein the inlet section and the channel system are configured to transport the sample of body fluid to, and to distribute it across the filtration membrane with a stepwise or gradually increasing capillarity from the inlet section to the filtration membrane; a metering function, configured to meter a predefined volume of the received body fluid; and at least one porous medium for receiving the transported sample of body fluid.