The invention relates to an array type paper chip for 2019-nCoV virus high-throughput detection and a manufacturing method of the array type paper chip. The array type paper chip comprises a glass substrate layer, a paper unit layer and a cell grid layer which are arranged in sequence from bottom to top, wherein the grid layer comprises N circular paper detection units with a diameter R being arranged in the form of an array; and the unit grids of the unit grid layer are in one-to-one correspondence to the paper detection units to separate the paper detection units. The array type paper chip is simple in structure, the manufacturing process is simple and stable, the finished products are stable, requirements on the processing environment and conditions are very low, and processing equipment is low in price. Moreover, the processing process does not revolve any chemical reagent, and therefore, the method is more environmentally friendly than methods such as ultraviolet lithography.

A computer-implemented method, computer program product and prototyping platform creates a design blueprint for a substrate-based microfluidic device. A design and prototyping platform receives at least one blueprint parameter and at least one constraint associated with a proposed substrate-based microfluidic device including a hydrophilic material and arrangement of a pattern of a hydrophobic material. The platform determines an arrangement of a plurality of microfluidic device elements as candidates for implementation of the proposed substrate-based microfluidic device and outputs a design blueprint of the proposed substrate-based microfluidic device.

A diagnostic device which enables measurement of fibrinogen concentration in a blood sample. The device comprises; a wettable testing substrate including viewing indicators which allow determination of a status of a test. The substrate has a first end and second end and intermediate therebetween a flow receiving zone, a flow path zone and a reaction zone; the reaction zone pre charged with at least one reagent. A blood sample to be tested is deposited near or in either of said flow receiving zone or said reaction zone, the sample reacting with the reagents inducing clotting of the sample. Water added to a dye added to said reaction zone, advances a distance along said substrate. The distance travelled along the substrate by the dye and through the sample is indicative of a measure of concentration of fibrinogen in said blood sample under test.

A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample.

The present disclosure provides a method for producing a microchannel device, which can form a channel that has high hydrophobicity, high solvent resistance as well, and also resistance to heat and damage, on demand with high accuracy, and produces the microchannel device at a low cost, while having high productivity. The method for producing a microchannel device includes: forming a channel pattern from a hydrophobic resin on a porous substrate by an electrophotographic method; melting the channel pattern by heat to allow the channel pattern to permeate into the porous substrate, thereby forming a channel in the inside of the porous substrate.

The present invention discloses an apparatus for detecting analyte in a liquid sample, comprising a cup body; a first receiving area for receiving a liquid sample; a flow-guiding channel through which a sample can be added or collected; the flow-guiding channel is in communication with the first receiving area, the bottom surface of the flow-guiding channel is a slope; wherein, the first receiving area and the flow-guiding channel are disposed in the cup body; the apparatus further comprises a secondary sampling port; the flow-guiding channel is a groove, in which is provided with a second receiving area; and the second receiving area includes a corner area for collecting samples for secondary sampling. The present invention further provides a method of using the apparatus for detecting an analyte in a liquid sample. The apparatus of the present invention can be used for detecting the presence or amount of an analyte in a liquid sample. When a liquid sample has extremely poor fluidity and/or the sample size is very small, the apparatus is still capable of detecting liquid samples, to facilitate operators to draw liquid samples for second confirmatory detection.

Provided is a microchannel device, which has high hydrophobicity, high mechanical strength, and safety and also has high solvent resistance, and thus has wider applicability. The microchannel device includes a porous substrate having formed therein channel walls each containing a cyclic olefin copolymer that is a copolymer of an alkene and a cyclic olefin.

The invention refers to a biosensor system for quick and multiplexed detection of biomarkers present in biological fluids. The biosensor system comprises a reusable array of at least two individual electrochemical cells (1a,1b,1c,1d,1e) coupled to a disposable fluidic component. Each cell can be addressed individually. The array includes a set of working electrodes (2a,2b,2c,2d) and at least one shared counter/reference electrode (5) in common for all the electrochemical cells, such that each electrochemical cell includes one working electrode and the shared counter/reference electrode. Preferably, the system includes a disposable paper component (8) having a reactive microfluidic component distributed in fluidic channels (9), isolated by hydrophobic barriers (10). The paper component (8) is operatively aligned with the array of electrochemical cells for the electrochemical detection by means of a polymeric cartridge. The multiplexed biosensor system features a reduced size, and that allows reduction of analysis costs and material waste.

A robotic arm of an automated pipetting system has a pipetting tip adapter and a slide switch to detect the presence of pipetting tips on the pipetting tip adapter is disclosed. The slide switch has first support member and second support member configured to slide relative to one another between first and second positions along a movement axis, an electrically conducting contact pad arranged on the first support member, an electrically conducting terminal physically attached to second support member in physical contact with the contact pad when support members are in first position, where the terminal is a first resilient and inherently stable wiping member expanding along the movement axis, first wiping member is not in physical contact with the contact pad when support members are in second position, and an electric current can flow between first wiping member and the contact pad when support members are in first position.

Disclosed herein are cellular cassettes for the storage, collection, and analysis of biological samples. The cellular cassette can enable easy sample collection and sealing of microwell arrays with semi-permeable membrane for stable storage and future processing of single cells. Also disclosed herein are systems and kits comprising one or more described cassettes. The described cassettes, systems, and kits can be used to create barcoded, single-cell sequencing libraries. Further described herein are methods of using the cassettes, systems, and kits.