A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device.

A device and method for catching a biological specimen removed from an individual. The device includes at least an inlet channel; an outlet channel; a main chamber having an interior wall and an exterior wall, wherein the main chamber is in fluid communication with the inlet channel and is in fluid communication with the outlet channel; and a receiving structure attached to at least a portion of the interior wall or the exterior wall of the main chamber and positioned such that it does not obstruct either the inlet channel or the outlet channel, wherein the receiving structure is further configured to receive a light emitting body for illuminating the main chamber of the device before catching the biological specimen removed from an individual. The device is connected to a medical scope and a vacuum system. When the device is placed under suction, the biological specimen is extracted and trapped on the removable filter of the device. The removable filter is disengaged from the main chamber of the device and deposited along with the biological specimen into a specimen container.

Disclosed is a device for moving a liquid in a substantially loss-free operation, the device made of at least a photothermal film; a pyroelectric crystal over the photothermal film; and a superomniphobic surface over the pyroelectric crystal, wherein the device is configured to move the liquid in the substantially loss-free operation with a beam of light.

A mobile device-based human pathogen rapid response diagnostic test system providing a partially disposable test kit and a system functioning within a mobile device software application. The diagnostic test system combines surfaces chemistry, thermochemical detection and automated histological digital imaging to reduce cradle-to-grave testing time relative to the state-of-the-art PCR methods.

A hematology test slide has the same or similar dimensions as a chemical reagent test slide and an immunoassay test slide so that it may be used with these other slides on a single clinical instrument. The hematology slide includes, in order from top to bottom, a slide housing having a top housing member, a top cover slip, a U-shaped, transfer tape spacer, a bottom cover slip, a base gasket and a base plate. The U-shaped spacer has a curved end portion which defines a sample deposit area, where a blood sample is pipetted thereon, and a pair of straight, parallel, spaced apart legs extending from the curved end portion. The legs define a read area. A blood sample deposited on the hematology slide at the sample deposit area will flow by capillary action to the read area, where optical measurements are made on the sample.

The present invention relates to a method for selecting and recovering products, comprising the following steps: providing an emulsion (6) comprising a plurality of drops (4) contained in a carrier fluid (10), each drop comprising an internal fluid (8), measuring at least one physical parameter for several drops (4) of the emulsion (6), classifying at least some of the drops (4) of the emulsion in a class based on measurements obtained during the measuring step, tagging at least some of the classified drops (4) based on the class of the drop (4), selectively recovering the drop (4) or part of the drop (4) using the tag of the drop or part of the drop (4).

In order to provide a biological sample analysis apparatus capable of preventing a container storing a sample from being charged and of measuring only a luminescence intensity of light emitted from the sample accurately, a biological sample analysis apparatus for rapid microbiological test analyzes light generated from a biological origin substance contained in a sample, and includes a holder that holds a plurality of containers storing the sample, a photodetector fixed at a predetermined position, a holder drive mechanism that drives the holder and sequentially positions each of the containers held by the holder at a detection position detected by the photodetector, and a neutralizer that neutralizes the containers held by the holder.

Provided are a fluorescence generating device and a digital PCR analysis system including the same. The fluorescence generating device includes a clad layer on a substrate, an optical waveguide arranged in a first direction within the clad layer, and a housing which is disposed on the optical waveguide and the clad layer and has a micro fluid channel extending in a second direction. The optical waveguide includes an input waveguide which is provided within one side of the clad layer and provides excitation light to a liquid drop within the micro fluid channel to generate fluorescent light, and an output waveguide which is provided within the other side of the clad layer and has an output inclined surface that reflects the fluorescent light.

At least one embodiment relates to a focusing arrangement for focusing particles or cells in a flow. The arrangement includes at least one channel for guiding the flow. The channel includes (i) at least one particle confinement structure having particle flow boundaries and (ii) at least one acoustic confinement structure having acoustic field boundaries adapted for confining acoustic fields. The acoustic field boundaries may be different from the particle flow boundaries, and the at least one acoustic confinement structure may be arranged with regard to the channel to at least partially confine acoustic fields in the channel.

To detect a target substance accurately and effectively, a target substance detection device 1 includes: a liquid-sample introducing plate 2 formed from a light-transmissive plate having a surface on which a liquid sample including a target substance and magnetic particles forming a conjugate with the target substance is introduced, and enabling propagating transmitted light of light irradiated from the rear face upward of the surface as propagated light; a rear face light irradiation unit 3 configured to be able to irradiate the liquid-sample introducing plate 2 with light from the rear face; a first magnetic field application unit 4 disposed on the side of the surface of the liquid-sample introducing plate 2, and configured to apply a magnetic field to move the conjugate in the liquid sample that is introduced on the surface of the liquid-sample introducing plate in the direction away from the liquid-sample introducing plate 2; and an optical-signal detection unit 5 disposed on the side of the surface of the liquid-sample introducing plate 2, and enabling detection of a change in optical signal based on the propagated light between before and after application of the magnetic field by the first magnetic field application unit 4.