An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.

This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.

A system for amplifying nucleic acids is disclosed which, in one embodiment, includes a fluidic device having a sample channel and a heat exchange channel disposed sufficiently close to the sample channel such that a heat exchange fluid in the heat exchange channel can cause a sample in the sample channel to gain or lose heat at desired levels. In one illustrative embodiment, the system further includes three reservoirs coupled to the heat exchange channel and a temperature control system configured to heat fluids stored in the respective reservoirs at different temperatures. One or more pumps and a controller are configured to cause fluid stored in the reservoirs to enter and flow through the heat exchange channel at different times.

A detection apparatus configured for PCR testing includes a carrier structure and a temperature detection module. The carrier structure is configured to carry a test tube, and the test tube is configured for containing a reagent and a specimen. The temperature detection module is disposed on the carrier structure and includes a heat transfer medium and a temperature sensor. The heat capacity of the heat transfer medium is approximately equal to a preset value, so as to match heat capacity of the reagent. The temperature sensor is configured to sense a temperature of the heat transfer medium. In addition, a method for detecting a temperature of the detection apparatus is also provided.

The present application discloses a carrier apparatus and a sequencing system. The carrier apparatus according to the embodiments of the present disclosure includes a carrier platform, a fluid connecting assembly, and a movement mechanism. The carrier platform includes a table surface, the table surface being detachably connected to a flow cell assembly; the flow cell assembly includes a flow cell, with a fluid inlet and a fluid outlet being respectively formed at both ends of the flow cell. The fluid connecting assembly includes a manifold arranged in correspondence with the fluid inlet and the fluid outlet. The movement mechanism drives the fluid connecting assembly to move, including: when the fluid connecting assembly is located at a first position, the fluid connecting assembly and the flow cell assembly form a fluid communication through the manifold with the fluid inlet and the fluid outlet; and when the fluid connecting assembly is located at a second position, communication between the fluid connecting assembly and the flow cell assembly is cut off. In the carrier apparatus according to the embodiments of the present disclosure, the fluid connecting assembly is driven by the movement mechanism to move relative to the flow cell assembly, such that the communication between the fluid connecting assembly and the flow cell assembly can be achieved or cut off. The carrier apparatus is simple in structure and convenient to operate.

A chip heat sink for a chip and a nucleic acid extraction device, where the chip has a channel for conveying a fluid, and on/off of the channel is controlled by an solenoid valve, the chip heat sink includes: a substrate, where the substrate has a first surface for placing the chip, and the first surface is provided with a first accommodating groove for accommodating an electromagnet; and a heat dissipation structure on the substrate and for dissipating heat from the electromagnet.

The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently.

This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.

A system for simulating flow within carbonate rock under reservoir conditions includes a substantially two-dimensional microfluidics device defining a flowpath therethrough, the substantially two-dimensional microfluidics device including a first wall comprising thin slices of carbonate rock, an opposing wall comprising transparent glass, a plurality of surrounding walls, and a throat defined within the flowpath to simulate flow through a porous structure. The system further includes a high-speed camera at or near the opposing wall and aimed at the first wall and the throat of the substantially two-dimensional microfluidics device, the high-speed camera operable to capture images and/or videos of fluid flow through the substantially two-dimensional microfluidics device.

The present invention is generally related to a sample tray for holding a sample of a material ready for a calorimetric or a thermoanalytical investigation and to an apparatus for a calorimetric or a thermoanalytical investigation comprising a calorimetric or a thermoanalytical measuring apparatus and said sample tray associated therewith. The sample tray includes a receptacle adapted to enclose an inner tray space for accommodating the sample and a heat transport means for causing heat to flow between the inner tray space and an outer side of the receptacle.