A system for preserving a surgically explanted tissue sample has a first packing station for placing the tissue sample in a selected container among a plurality of containers of different sizes. Each container has a hermetic lid (50) with an opening (33) equipped with a non-return valve (51). The system also has a final packing station equipped with a filling system for filling the selected container with a preservative substance, including a nozzle-holding head (28) mounted movable on a vertical guide (29). A method is also described which provides for the selection of the container based on the evaluation of the volume of the tissue sample, the hermetic closure of the container immediately after the insertion of the tissue sample, and the filling of the container by means of a nozzle (31) of a filling system inserted in the non-return valve (51) of the hermetic lid (50).

The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.

An analysis device and method for testing a biological sample using a receivable cartridge having at least one actuator for actuating a valve of the cartridge. The actuator has a pneumatically loaded membrane and an actuation element that is coupled to the membrane, the return movement into an unactuated position being performed preferably as a result of restoring forces of the membrane.

Reagent delivery systems, which can include a reagent trough and a pump system, are useful for delivering liquids to a laboratory workbench. Processing samples on the laboratory workbench can result in a large amount of liquid waste. Described herein are reagent troughs, pump systems, reagent delivery systems, waste management systems, and methods of using the same.

The disclosed embodiments related to an apparatus and methods for biological sample processing enabling isolation and concentration of microbial or pathogenic constituents from the sample. Sample may be obtained directly from a specimen container, such as a vacutainer, and processed directly without risk of user exposure. The disclosed methods and apparatus provide a convenient and inexpensive solution for rapid sample preparation compatible with downstream analysis techniques.

Disclosed is a robotic apparatus for building a multidimensional object. The apparatus includes extruder unit, support structure, plurality of motor units, and modeling platform. The extruder unit receives material to build multidimensional object. The extruder unit includes plurality of nozzles, and spring steel valve. The nozzles includes changeable orifices to extrude pre-defined patterns of materials. The spring steel valve isolates cross flow contamination of materials to allow positive extrusion of materials and restricts the backflow of materials. The extruder unit moves concurrently in forward and reverse direction while extruding materials. The support structure includes sides, and rails. The sides form outer surface of support structure. The rails are integrated with sides to form multidimensional path for extruder unit. The motor units control elevation and movement of extruder unit. The modeling platform is rotatable and provides build surface to support multidimensional object. The modeling platform moves in forward and reverse direction.

The microfluidic board comprises a plurality of matrix units, wherein each matrix unit is a stacked arrangement comprising a driving portion comprising an actuator, a pump portion in contact with the driving portion and comprising a pump, a channel portion in contact with the pump portion and comprising one or more channels, and a chamber portion in contact with the channel portion and comprising a chamber, wherein the one or more channels are configured to direct fluid between the pump and the chamber, and wherein the actuator is configured to generate a force to drive the pump upon receiving of an input energy.

Disclosed are apparatuses, methods, and method of manufacture of a microfluidic device for detecting biomolecules in sweat, and a biosensor patch for detecting biomolecules in sweat, in which the microfluidic device and a biosensor are combined, the device and the patch being capable of detecting various target molecules present in sweat by electrochemical signals and also detecting the concentration of a target molecule. The microfluidic device includes a fluidic passing layer including an inlet part, a sensing element in communication with the inlet part, a reagent storage part in communication with the sensing element part, and a disposer in communication with the sensing element, and a fluidic connection layer including a microfluidic tube arranged in a vertical direction to the inlet part, a sensing space provided between the sensing element and the biosensor, and a reagent storage space positioned below the reagent storage part, the fluidic connection layer being disposed below the fluidic passing layer.

Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

A method and system for processing a sample in a fluid is provided. An assembly comprising a cap prefilled with a fixative solution, a valve, and a container for storing a tissue sample are provided. The valve is adapted to be situated between the cap and the container such that fluid can flow from the cap into the container when the assembly is upright, but the fluid cannot backflow from the container to the cap when the assembly is horizontal or inverted.