Embodiments of the disclosure provide a nucleic acid extraction microfluidic chip, and a nucleic acid extraction device and method. The nucleic acid extraction microfluidic chip includes a channel plate including: a mixed lysis zone, an extraction zone adjacent to the mixed lysis zone, a gas-pressure driven port in communication with an exterior, a first type of channel communicating the mixed lysis zone with the extraction zone, and a second type of channel communicating the extraction zone with the gas-pressure driven port; a cover plate opposite to the channel plate, wherein the cover plate includes a sample inlet and a liquid inlet through hole in a location corresponding to the mixed lysis zone; and a solution accommodating cavity, on a side of the cover plate away from the channel plate, wherein the solution accommodating cavity communicates with the mixed lysis zone of the channel plate through the liquid inlet through hole.

A centrifugal reaction microtube, centrifugal reaction device and its centrifugal examination method are provided to achieve easy, quick operation, safety, energy saving, precision, cost effectiveness, and prevention of contamination by controlling a centrifugal force and using a uni-directional valve in the centrifugal reaction microtube.

A fluidic device includes: a circulation flow path; and a capture part arranged on the circulation flow path and configured to capture a sample substance in a solution and/or a detection part arranged on the circulation flow path and configured to detect a sample substance in a solution. A method of capturing a sample substance that is bound to a carrier particle, using a fluidic device which includes a circulation flow path and a capture part arranged on the circulation flow path and configured to capture the carrier particle and in which the circulation flow path has two or more circulation flow path valves, includes: an introduction step of, in a state where the circulation flow path valve is closed, introducing a solution that includes a sample substance to at least one of partitions partitioned by the circulation flow path valve and introducing a solution that includes a carrier particle which is bound to the sample substance to at least another of the partitions; a mix step of opening all of the circulation flow path valves and circulating and mixing a solution in the circulation flow path; and a capture step of capturing the carrier particle by the capture part.

Systems and related temperature calibration methods. In accordance with a first implementation, an apparatus includes a flow cell interface, a temperature control device, an infrared sensor, and a controller. The flow cell interface includes a flow cell support and the temperature control device is for the flow cell support. The controller is to command the temperature control device to cause the flow cell support to achieve a temperature value, cause the infrared sensor to measure an actual temperature value of the flow cell support, and calibrate the temperature control device based on a difference between the commanded temperature value and the actual temperature value.

The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve element, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element.

A sampling apparatus can have an elongate tube and a liquid partitioning unit, first port can receive an incoming flow of test liquid and a second port may be coupled to the elongate tube. The liquid partitioning unit can combine the flow of test liquid with a plurality of partitioning elements to define a plurality of discrete liquid samples for movement along and storage in the elongate tube.

An analytical toilet comprising a bowl adapted to receive excreta; one or more conduits for transporting a sample from the bowl; one or more fluid sources in fluid connection with the one or more conduits; and one or more microfluidic chips, comprising at least one fluid inlet; at least one fluid outlet; and a sensor configured to detect at least one property of an excreta sample is disclosed.

A well plate assembly with an interior channel system in the well plate lid provides a more efficient and uniform distribution of fluid into a receptacle positioned below the well plate lid. The channel system in the lid allows air, or other fluid, to pass through with the use of a pump to each of a plurality of channels in the receptacle. Inlet and outlet valves in the lid prevent a gasket positioned between the lid and the receptacle from releasing contact with the receptacle due to high pressure experienced during the injection of fluid into the assembly. Specifically, pressure under a specified tolerance passes through the inlet valves, and if the pressure within the channel system exceeds the limit of the outlet valve, the outlet valve opens and allows air to escape the lid safely without disturbing the fluid flow into the channels below.

A testing device (20, 120, 220, 290, 320, 420, 520, 620, 720, 820, 1020, 1120) is provided for testing for the presence of particulate in a liquid (22). The testing device (20, 120, 220, 290, 320, 420, 520, 620, 720, 820, 1020, 1120) includes a liquid container (30, 730) for containing the liquid (22); a filter (32, 132, 732), disposed in or downstream of the liquid container (30, 730); a liquid-pressure source (34, 734), which is arranged to apply pressure to drive the liquid (22) contained in the liquid container (30, 730) through the filter (32, 132, 732); and a filter chamber (36, 136, 236, 336, 736) that is (a) disposed downstream of the liquid container (30, 730), (b) shaped so as to define an inlet (38, 138, 238, 738, 838), and (c) in fluid communication with the filter (32, 132, 732). Other embodiments are also described.

An apparatus and method for simple, low power, automated processing of biological samples through multiple preparation and assay steps. The apparatus and methods described facilitate the point-of-care implementation of diagnostic assays. The apparatus includes mechanical actuating elements using linear and/or rotational motion.