An exhaust line assembly for a bottle attachment apparatus for handling liquids has an outrigger-type mount, an exhaust line which is disposed and guided in the mount and which terminates in a tip, and a mounting lug which has a closure cap attached to the end thereof and which is fastened to the exhaust line assembly, the tip of the exhaust line being closable by way of the closure cap. The mounting lug at that end thereof which is fastened to the exhaust line assembly is articulated so as to be pivotable by a rotary joint which has a physically present axis of rotation.

Reagent reservoirs and related systems and methods are disclosed. In accordance with a first implementation, an apparatus includes a system and a reagent reservoir. The system includes a reagent reservoir receptacle. The reagent reservoir is received within the reagent reservoir receptacle and has a body and a fluidic port. The body defines a storage chamber, a sipper chamber, and a fluidic sinus fluidly coupling the storage chamber and the sipper chamber. The fluidic port is fluidly coupled to the sipper chamber.

A collection container for biological samples is described. In one embodiment, the collection container includes a receptacle and a lid with a sampling port. The sampling port is coupled to an aspiration tube and allows access to the contents of the receptacle. A needle-free fitting allows a mating device to be coupled to the sampling port. A valve automatically closes to prevent the sample from escaping through the sampling port when a mating device is not coupled.

The present invention relates to sample-to-answer systems, devices, cartridges, and method of using the same for detecting the presence of microorganisms in a sample, such as bacteria.

The present invention provides methods and devices for simple, low power, automated processing of biological samples through multiple sample preparation and assay steps. The methods and devices described facilitate the point-of-care implementation of complex diagnostic assays in equipment-free, non-laboratory settings.

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Methods and systems and related compositions for separating through a solid matrix a mixture comprising a nucleic acid together with a target compound having a water solubility equal to or greater than 0.01 mg per 100 mL, which can be used for managing fluid flow, biochemical reactions and purification of the nucleic acid or other target analytes.

An easy to use test device for the testing of liquids comprising a primary chamber to receive an initial liquid sample and a multiplicity of secondary regions arranged to each receive an aliquot of the initial liquid sample from the primary chamber, wherein the test device is movable in use between two positions, a first position and a second position. The device is especially suitable for carrying out on-site microbial assays with a minimal requirement for user expertise and additional apparatus. The invention also provides related methods and apparatus.

A washing device comprises a fluid dispenser that operably directs a cleaning fluid to contact one or more objects to be cleaned, the one or more objects to be cleaned being contained by the washing device, a dispensing line directing the cleaning fluid to the fluid dispenser, a compressed air source, an air valve selectively controlling flow of air from the compressed air source into the dispensing line, a cleaning fluid source, a pump selectively pumping the cleaning fluid from the cleaning fluid source into the dispensing line, and a controller. The controller alternatingly activates (a) the pump to pump the cleaning fluid from the cleaning fluid source into the dispensing line and (b) the air valve to force the cleaning fluid from the dispensing line via the fluid dispenser.

An apparatus with a self-contained, tunable, microfluidic pumping system that utilizes the high air permeability of the matrix material to actuate fluid flow in a network of fluidic microchannels and microstructures is provided. The pumping relies upon partial evacuation of degas/vacuum channels that are located next to the fluid channels to degas air from the fluid channels or structures producing a reduction of pressure in the fluidic channel leading to the flow of fluid from an inlet at atmospheric pressure through the device. The solution is isolated from the pumping apparatus since the liquid does not pass through the diffusion barriers. The apparatus and method can also provide bubble-free microfluidic pumping, without any auxiliary equipment or device pre-treatment, and can fill dead-end channels and chambers, providing a powerful liquid handling tool for a broad range of applications.