Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Provided is a cell culture test device including a plurality of well units. Each of the well units includes a first inlet portion through which a first fluid is introduced, a first accommodation space communicating with the first inlet portion to accommodate a flow of the first fluid introduced through the first inlet portion, a second inlet portion through which a second fluid is introduced, and a second accommodation space in which the second fluid is accommodated. The second accommodation space accommodates an island structure connected with an island-connecting structure extending from the wall surface of the second accommodation space. A third inlet portion through which an antibiotic is loaded is formed above the island structure. The antibiotic loaded through the third inlet portion is fixedly accommodated on the inner and outer surfaces of the island structure.

Provided is a channel device that is capable of increasing the concentration of fine particles in a liquid only by use of fluid-dynamic flows without relying on electrostatic interactions. A channel device (1) in accordance with an embodiment of the present invention includes: a main channel (11) configured to allow a liquid containing fine particles to flow therethrough; a chamber (15) that is provided at an end of the main channel (11) and that is configured to store target fine particles which have increased in concentration; and a side channel (12) that is connected to a side face of the main channel (11) and that is configured to allow unwanted liquid to drain therethrough, wherein at least one of a height and a width of the side channel (12) is smaller than a particle size of the fine particles.

Embodiments of the invention provide a microfluidic chip having microfluidic structures formed on a surface. The structures form an input channel, an output channel, auxiliary channels, and a hydraulic resistor structure connecting the input channel to the output channel via the auxiliary channels. The resistor structure includes N flow resistor portions (N≥2), which are connected to the auxiliary channels. The chip further includes at least N−1 actuatable valves, which are arranged in respective ones of the auxiliary channels. The actuation state of the valves can determine the effective hydraulic resistance of the resistor structure. The valves can be electrogates, each including a liquid-pinning trench arranged in a respective one of the auxiliary channels that define a flow path for a liquid introduced therein, so as to form an opening that extends across said flow path. Each electrogate can further include an electrode extending across the flow path.

A microfluidic device comprises upper and lower spaced apart substrates defining a fluid chamber therebetween; an aperture for introducing fluid into the fluid chamber; a plurality of independently addressable array elements, each array element defining a respective region of the fluid chamber; and control means for addressing the array elements. The control means are configured to: determine that a working fluid has been introduced into a first region of the fluid chamber; and provide an output to a user to indicate that the working fluid is present in the first region. Once the working fluid is in the first region, the fluid applicator used to dispense the fluid can be removed without any risk of accidentally withdrawing dispensed working fluid from the microfluidic device. In the case of manual loading of the working fluid the output may inform a user that it is safe to remove the applicator, or in the case of automatic or robotic loading the output signal may be provided to the system controlling the automatic or robotic loading of fluid so that the system can remove the fluid applicator.

Disclosed are a biosensing test strip (100, 200, 300, 500, 600, 700, 800, 900, 1000, 1100) and a biosensing test method. The biosensing test strip (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100) comprises: a reaction layer (120, 220, 720, 820) provided with a reaction flow channel (121, 221, 821, 920, 1020); a partition plate layer (130, 230) located above the reaction layer (120, 220, 720, 820) and covering the reaction flow channel (121, 221, 821, 920, 1020); an exhaust layer (140, 240, 540, 640) located above the partition plate layer (130, 230), with the exhaust layer (140, 240, 540, 640) being provided with an exhaust flow channel (141, 241, 550, 650); and a communication hole passing through the partition plate layer (130, 230) to enable the exhaust flow channel (141, 241, 550, 650) to be in communication with the reaction flow channel (121, 221, 821, 920, 1020).

Devices and methods for multi-well plate liquid distribution are provided. Devices herein provide a plurality of dispensing stations configured to receive and dispense or disburse liquid to the wells of a multi-well plate. The dispensing stations include dispensing surfaces configured to receive liquid droplets dispensed by manual or automatic pipettes. The dispensing surfaces are configured to retain received liquids until force is applied and distribution to the wells of the multi-well plate occurs. Devices and methods provided herein increase the consistency of laboratory results in procedures requiring liquid distribution.

The present invention provides a cartridge, a detection method, and a detection device capable of stabilizing the liquid level of a sample accommodated in a chamber in a predetermined state. A cartridge 20, that is rotated around a rotating shaft 42 for detecting a target substance, is provided with a chamber 100 in which a sample containing a target substance is stored. The chamber 100 includes a first region 110 in which a sample is stored, a second region 120 disposed at a position closer to the rotating shaft 42 than the first region 110, and a protrusion 130 protruding from a position between the first region 110 and the second region 120 to the inner side of the chamber 100.

There is provided an arrangement (100) which allows for mixing a first fluid with a second fluid at a predetermined volume mixing ratio in a capillary driven fluidic system. The arrangement (100) allows filling an initially empty mixing chamber (110) with the first fluid. The arrangement then allows emptying a predetermined fraction of the first fluid from the mixing chamber (110) such as to form an empty space in the mixing chamber (110). The arrangement then allows filling the empty space of the mixing chamber (110) with the second fluid, thereby allowing a predetermined volume of the first fluid to mix with a predetermined volume of the second fluid over time.

There is provided a microfluidic device for reversing a flow through a microfluidic channel. The microfluidic device comprises a first microfluidic channel extending between a first inlet and a first outlet, a second microfluidic channel which fluidically connects a first point of the first microfluidic channel to a second outlet via a first valve, a third microfluidic channel which fluidically connects a second point of the first microfluidic channel to a second inlet via a second valve, the second point being located between the first point and the first outlet, and at least one circuit for opening the first valve and the second valve. The first and the second valves are arranged to be initially closed, Upon opening of the first and the second valve during use, the flow direction through the first microfluidic channel between the first point and the second point is reversed.