The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.

A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reaction between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

Methods and systems for manipulating drops in microfluidic channels are provided.

Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.

The subject matter of the present invention is a microfluidic process for treating and analysing a solution containing a biological material, comprising a step of introducing the solution into microchannels of a microfluidic circuit (1), a step of forming drops of this solution, under the effect of modifications of the surface tension of the solution, a step of moving the drops to one or more drop storage zones(s) (130), under the effect of modifications of the surface tension of the drops, a step of treating the drops and a step of analysing the drops.

Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

Organ-on-chip platforms with reduced fluid volumes include circulating fluid volumes of below 1000 ?L, preferably about 500 ?L or less. The platforms are adjustable for culturing cells with varied oxygen demand at various seeding densities. The platforms include at least one lane, wherein each lane includes at least one cell culture well, at least one oxygenator for fluid oxygenation, and a pump system containing at least one pump per lane. The oxygenator may include a separate fluid path for oxygenating the fluid, which allows controlling and measuring the oxygen concentration in the fluid, shortening the diffusion length, and passively diffusing oxygen. Provided are also different configurations for the oxygenator, fluid circulation in the platforms, attachment means for securing scaffolds to culture wells, and pneumatic plates.

Biological sample testing devices, and associated systems and methods, are disclosed herein. In some embodiments, the biological sample testing device includes a slide, a spacer layer carried by the slide, and a cover slip carried by the slide over the spacer layer. The spacer layer includes one or more wells, each of which extend horizontally along a first axis from an inlet at a first side of the biological sample testing device to an outlet at a second side of the biological sample testing device opposite the first side. Each well is defined by a set of curved sidewalls that extend from the inlet to the outlet. Further, the set of curved sidewalls define an asymmetric shape for the well about a second axis perpendicular to the first axis. The shape manages a flow of a biological sample to reduce a chance of bubbling within the well.

A microorganism culture device and a method of using the device. The device includes an open chamber, wherein microorganisms are likely to be deposited within a liquid for subsequent study. The open chamber simplifies the deposition of the microorganisms. The chamber is further provided with retention features, whereby microorganisms can be retained therein. In addition, the device includes an overflow area, wherein capillary structures are configured to retain excess liquid overflowing from the open chamber, e.g. when covering the device with a cover. As such, it allows for confining microorganism in the chamber, while excess fluid is captured externally, e.g. to seal the device with a cover.