The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

Roller packages (IO) for grinding devices (70), comprising a first roller (II), which is maintained by at least one first bearing body (13), and a second roller (12), which is maintained by at least one second bearing body (14). The first bearing body (13) and the second bearing body (14) are prestressed against each other and comprise stop elements (17, 19) with stop surfaces (18, 20), the contact of which counteracts a contact of the rollers (II, 12). The rotational position of the first stop element (17) determines the minimum width of the grinding gap. Also disclosed are grinding devices (70), methods for operating a roller group (IO) and methods for determining the radial force acting between the rollers (II, 12) of a roller group (IO).

Roller packages (IO) for grinding devices (70), comprising a first roller (II), which is maintained by at least one first bearing body (13), and a second roller (12), which is maintained by at least one second bearing body (14). The first bearing body (13) and the second bearing body (14) are prestressed against each other and comprise stop elements (17, 19) with stop surfaces (18, 20), the contact of which counteracts a contact of the rollers (II, 12). The rotational position of the first stop element (17) determines the minimum width of the grinding gap. Also disclosed are grinding devices (70), methods for operating a roller group (IO) and methods for determining the radial force acting between the rollers (II, 12) of a roller group (IO).

A milling installation and a corresponding method for the milling and/or crushing of granular fruits or the like provide optimized closed-loop and open-loop control. A central closed-loop and open-loop control apparatus provides the optimized control of the milling installation. Memory-programmable controllers are connected bidirectionally via network interfaces to the central closed-loop and open-loop control apparatus and/or addressed and controlled by transmitted control parameters. The control apparatus controls centrally, in particular in a web-based manner, the processing apparatuses of different passages of the same or different mills. During the generation of the control parameters, a distinction is drawn between passage-specific and environment-specific management/operating parameters.

A milling installation and a corresponding method for the milling and/or crushing of granular fruits or the like provide optimized closed-loop and open-loop control. A central closed-loop and open-loop control apparatus provides the optimized control of the milling installation. Memory-programmable controllers are connected bidirectionally via network interfaces to the central closed-loop and open-loop control apparatus and/or addressed and controlled by transmitted control parameters. The control apparatus controls centrally, in particular in a web-based manner, the processing apparatuses of different passages of the same or different mills. During the generation of the control parameters, a distinction is drawn between passage-specific and environment-specific management/operating parameters.

A self-optimizing, adaptive product processing system and a corresponding method for grinding and/or crushing cereals and seeds. The grinding and/or crushing takes place in at least one roller mill which includes a roller pair. So as to detect the temperature of the surfaces of the rollers, at least two temperature sensors are disposed on at least one of the rollers. The detected temperature measurement values are used for optimal adjustment and signal generation of the roller setting.

A self-optimizing, adaptive product processing system and a corresponding method for grinding and/or crushing cereals and seeds. The grinding and/or crushing takes place in at least one roller mill which includes a roller pair. So as to detect the temperature of the surfaces of the rollers, at least two temperature sensors are disposed on at least one of the rollers. The detected temperature measurement values are used for optimal adjustment and signal generation of the roller setting.

A roller mill module with a fixed grinding roller with a first grind surface rotatably supported within a grind area between a first drive end and a second drive end of a support structure; an adjustable grinding roller with a second grind surface rotatably supported within the grind area; the adjustable grinding roller movable with respect to the fixed grinding roller to adjust a grind gap between the first grind surface and the second grind surface; a drive shaft of the fixed grinding roller and a drive shaft of the adjustable grinding roller extending from the first and the second drive ends of the support structure; and a sample port provided in a front side of the support structure; a sample passage coupled to the sample port extending to a position below the grind area and opposite a sampler stop surface.

A roller mill module with a fixed grinding roller with a first grind surface rotatably supported within a grind area between a first drive end and a second drive end of a support structure; an adjustable grinding roller with a second grind surface rotatably supported within the grind area; the adjustable grinding roller movable with respect to the fixed grinding roller to adjust a grind gap between the first grind surface and the second grind surface; a drive shaft of the fixed grinding roller and a drive shaft of the adjustable grinding roller extending from the first and the second drive ends of the support structure; and a sample port provided in a front side of the support structure; a sample passage coupled to the sample port extending to a position below the grind area and opposite a sampler stop surface.