A negative pressure vest includes a housing defining a fixed, minimum interior volume. The housing has a neck opening, a pair of arm openings and a trunk opening. Each of the neck and arm openings includes a sealing member. A one-way check valve communicates between the interior volume and an ambient environment surrounding an exterior of the housing. The one-way check valve is openable at a pressure greater than an ambient atmospheric pressure. A one-way pressure-relief valve communicates between the interior volume and the ambient environment. The one-way intake valve is openable at a predetermined negative pressure. A method of providing negative pressure to the user's thorax is also provided.

A therapy system is operable to deliver at least one respiratory therapy to a patient. For example, therapy system may be operable to deliver any one or more of the following therapies: a high frequency chest wall oscillation (HFCWO) therapy, a positive expiratory pressure (PEP) therapy, a nebulizer therapy, an intermittent positive pressure breathing (IPPB) therapy, a cough assist therapy, a suction therapy, a bronchial dilator therapy, and the like. The therapy system is contained in a housing supported by a mobile stand.

A method for treating, preventing, or ameliorating cardiovascular disease in a subject involves exposing the subject for an effective duration to a condition of hypobaric normoxia or hypobaric hyperoxia. An apparatus or system useful for treating, preventing, or ameliorating cardiovascular disease includes an airtight chamber configured to accommodate and enclose a subject, and including at least one hatch to allow entry or exit of the subject; a vacuum source for adjusting pressure within the chamber to a level sufficient to maintain hypobaria; and a gas source for introducing one or more gases into the chamber, such as oxygen in an amount sufficient to produce a condition of normoxia or hyperoxia within the chamber, while maintaining hypobaria.

A method for treating, preventing, or ameliorating cardiovascular disease in a subject involves exposing the subject for an effective duration to a condition of hypobaric normoxia or hypobaric hyperoxia. An apparatus or system useful for treating, preventing, or ameliorating cardiovascular disease includes an airtight chamber configured to accommodate and enclose a subject, and including at least one hatch to allow entry or exit of the subject; a vacuum source for adjusting pressure within the chamber to a level sufficient to maintain hypobaria; and a gas source for introducing one or more gases into the chamber, such as oxygen in an amount sufficient to produce a condition of normoxia or hyperoxia within the chamber, while maintaining hypobaria.

Methods for treating fluid overload in a subject comprise shifting fluids directly and non-invasively from an interstitial compartment of the subject to skin of the subject through controlled local sweating. Methods of the invention allow for removal of excess fluid from the interstitial compartment of the subject and treat fluid overload in the subject. Sweat stimulation systems comprise a chamber and first and second relative humidity sensors. The chamber is sized to fit around a body part of a subject, comprises an inlet and an outlet, and is configured such that air flows through the chamber from the inlet to the outlet. The first relative humidity sensor is operably located inside the inlet, and the second relative humidity sensor is operably located proximate the outlet.

A therapy system is operable to deliver at least one respiratory therapy to a patient. For example, therapy system may be operable to deliver any one or more of the following therapies: a high frequency chest wall oscillation (HFCWO) therapy, a positive expiratory pressure (PEP) therapy, a nebulizer therapy, an intermittent positive pressure breathing (IPPB) therapy, a cough assist therapy, a suction therapy, a bronchial dilator therapy, and the like. The therapy system is contained in a housing supported by a mobile stand.

Medical techniques include systems and methods for administering a positive pressure ventilation, a positive end expiratory pressure, and a vacuum to a person. Approaches also include treating a person with an intrathoracic pressure regulator so as to modulate or upregulate the autonomic system of the person, and treating a person with a combination of an intrathoracic pressure regulation treatment and an intra-aortic balloon pump treatment.

Medical techniques include systems and methods for administering a positive pressure ventilation, a positive end expiratory pressure, and a vacuum to a person. Approaches also include treating a person with an intrathoracic pressure regulator so as to modulate or upregulate the autonomic system of the person, and treating a person with a combination of an intrathoracic pressure regulation treatment and an intra-aortic balloon pump treatment.

Systems and methods related to the field of cardiac resuscitation, and in particular to devices for assisting rescuers in performing cardio-pulmonary resuscitation (CPR) are described herein. The system includes an applicator device configured to provide ACD CPR treatment to a patient's chest according to a plurality of phases at least one sensor configured to be coupled to the patient's chest and to measure at least one parameter related to the ACD CPR treatment and information for determining whether at least one transition point of the ACD CPR treatment has been reached; and one or more processors configured to provide a feedback signal based on a parameter for administering ACD CPR treatment to the patient's chest according to a desired treatment protocol.

Systems and methods related to the field of cardiac resuscitation, and in particular to devices for assisting rescuers in performing cardio-pulmonary resuscitation (CPR) are described herein. The system includes an applicator device configured to provide ACD CPR treatment to a patient's chest according to a plurality of phases at least one sensor configured to be coupled to the patient's chest and to measure at least one parameter related to the ACD CPR treatment and information for determining whether at least one transition point of the ACD CPR treatment has been reached; and one or more processors configured to provide a feedback signal based on a parameter for administering ACD CPR treatment to the patient's chest according to a desired treatment protocol.