A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat. The beads may be trapped in the form of an array of localized magnetic field regions.

The present disclosure relates to systems and methods for high efficiency electronic sequencing of nucleic acids and molecular detection.

A method and apparatus for manipulating polarizable dielectric particles. The method includes positioning a liquid containing the particles above a surface of a piezoelectric material (2). The method also includes inducing a shear-horizontal surface acoustic wave in the piezoelectric material (2), thereby to form a time-varying non-uniform evanescent electric field extending into the liquid. The method further includes using the time-varying non-uniform evanescent electric field to apply a force to at least some of the particles (50, 52) by dielectrophoresis.

An aerosol capture device according to the present invention may include a housing including an air inlet through which air introduced, and an air discharge part through which the introduced air flows and the flowing air is discharged, a capture liquid that is accommodated in the housing and captures an aerosol in the air flowing inside the housing, and a concentration part that is disposed inside the housing, is in contact with the capture liquid, and concentrates the aerosol captured in the capture liquid.

Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.

A dielectrophoresis based biosensor for evaluating mechanical and electrical properties of a biological cell is disclosed. Said dielectrophoresis based biosensor comprises a substrate having a surface. The biosensor further comprises a source electrode, a ground electrode and a sensor electrode is positioned on the surface of said substrate, where a dielectrophoretic force is exerted by said electrodes. The source electrode and the ground electrode are separated by a predetermined distance, and the sensor electrode is positioned between the source electrode and the ground electrode. The dielectrophoresis based biosensor further includes a microfluidic channel positioned on the substrate to place the biological cell at a desired position to evaluate the mechanical and electrical properties of a biological cell. The present invention also discloses a method of fabricating dielectrophoresis based biosensor according to an embodiment, and a method of performing test by using dielectrophoresis based biosensor.

A dielectrophoretic separator has a separator vessel having a fluid ingress at a first side and a fluid egress at a second side, an electrode electrically connected to a power source and contained within the vessel, along the central axis, a plurality of high permittivity dielectric rods within the vessel positioned around and parallel to the electrode, wherein the electrode has a first polarity and the vessel has a second polarity such that an electromagnetic field is generated between the electrode and the vessel. A method of performing a separation cycle has the steps of: i) powering up an electrode within a vessel such that the electrode and vessel have an opposite polarity, wherein a plurality of high permittivity dielectric rods are contained within the vessel, ii) the fluid passing through channels between the rods, iii) the solid particles within the fluid being retained against the rods by electrical field(s).

An analysis device (200) analyzes a crossover frequency at which a dielectrophoretic force on dielectric particles switches from a repulsive force to an attractive force or from the attractive force to the repulsive force, comprising a flow channel (5), a pair of electrodes (22, 23), a power supply (24), an imaging unit (25) and an analyzer (26). Through the flow channel (5), a sample solution containing the dielectric particles in the dielectrophoretic liquid flows. The pair of electrodes (22, 23) are arranged in the first channel. The power supply (24) applies a frequency-modulated AC voltage to the first electrodes (22, 23). The imaging unit (25) captures an image of a movement trajectory of each of the dielectric particles flowing between the electrodes (22, 23) in the flow channel. The analyzer (26) obtains the crossover frequency of the dielectric particles based on the captured image of the movement trajectory.

Electro-kinetic separation processes for removing solid particles from hydrocracker process streams are provided herein.

Provided is a dielectrophoresis-based dynamic Surface-Enhanced Raman Spectroscopy (SERS) nanoelement for the classification and analysis of metabolites. A method for analyzing metabolites using a dielectrophoresis-based dynamic SERS nanoelement according to an embodiment of the present invention may comprise the steps of: preparing a dynamic SERS nanoelement in which a surface region is formed as an array; applying voltage to the dynamic SERS nanoelement; and classifying the metabolites of an analysis subject according to region by controlling the polarity of the dynamic SERS nanoelement according to the voltage applied.