A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part (18) that couples to, or defines, a blade (10) of a centrifuge at a radial distance from a centrifuge axis (12); a chip part (20) that holds the chip at an orientation having a normal not perpendicular to the axis; a one degree of freedom (DoF) joint (16) between the blade part and the chip part; and a force applicator (28) which bears on the chip part at a fixed set of one or more points, which do not surround, and are not surrounded by, the joint.

A centrifuge rotor includes a rotor body having a base, a sidewall, and a top. The top defines an opening that provides access to an annulus cavity inside the rotor body. A cover is removably attachable to the rotor body to seal the annulus cavity. A drive hub extends from a portion of the base of the rotor body and couples to a drive shaft of a centrifuge motor. The rotor body is sized to receive one or more sample containers in the annulus cavity, and to constrain the one or more sample containers inside the annulus cavity between the base, the sidewall, and the top when the one or more containers are advanced radially against the sidewall.

Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge far performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the microfluidic device. The integrated fluidic processing cartridge may include a supernatant chamber the extraction of a supernatant thereto, and a diluent chamber for diluting a suspension collected in the centrifugation chamber.

Systems, methods and devices are provided for the automated centrifugal processing of samples. In some embodiments, an integrated fluidic processing cartridge is provided, in which a centrifugation chamber is fluidically interfaced, through a lateral surface thereof, with a microfluidic device, and wherein the integrated fluidic processing cartridge is configured to be inserted into a centrifuge for centrifugation. A cartridge interfacing assembly may be employed to interface with the integrated fluidic processing cartridge for performing various fluidic processing steps, such as controlling the flow of fluids into and out of the centrifugation chamber, and controlling the flow of fluids into the microfluidic device, and optionally for the further fluidic processing of fluids extracted to the micro-fluidic device. The integrated fluidic processing cartridge may include a supernatant chamber the extraction of a supernatant thereto, and a dilutent chamber for diluting a suspension collected in the centrifugation chamber.

A centrifugal cartridge or disk used for extraction of light supernatant fractions from fluid samples is described, particularly for non-homogenous fluid biological samples such as whole blood. The device may be used to collect cell-free blood plasma or a fraction of whole blood containing target cells such as leukocytes. Single or multiple channels are described, including channels with passive valves, gaskets, receiving cavities, inlet holes, capillary wicking ridges, distal cavities for cell retention, separator gel, and density medium. Centrifugal action causes whole blood in a receiving cavity to pass into one or more channels where it separates into blood cells, plasma and optionally fractions of an intermediate density. After spin, the plasma returns to the receiving cavity by way of the one or more channels for extraction through the inlet hole or other inwardly located hole. Disposable cartridges are constructed of monolithic top and bottom plates, which may be joined together by an elastomeric outer seal.

The present invention relates to a centrifuge for cleaning a reaction vessel unit, comprising a rotor and a rotor chamber in which the rotor is positioned and supported in rotary fashion. The rotor chamber is delimited by a housing having a drainage channel beneath the rotor. Adjacent to the channel, the inner surface of the housing is embodied in the form of a funnel that feeds into the channel. This centrifuge does not require a suction pump for suctioning liquids from the rotor chamber. In addition, the centrifuge can be provided with an exchangeable module that delimits the rotor chamber and includes the rotor. The exchangeable module can be exchanged after a predetermined amount of use and replaced with another. It is also possible, however, for the module to be removed from the centrifuge, cleaned, and re-inserted.

A rotor system comprises a rotor constructed and arranged to rotate about an axis of rotation. A source of electromagnetic radiation is positioned at a first position of the rotor, the source of electromagnetic radiation configured to emit electromagnetic radiation at one or more wavelengths. The rotor system further includes a sample region. A detector is positioned at a second position of the rotor, the detector constructed and arranged to receive electromagnetic radiation that traverses at least a portion of the sample region.

Apparatus and associated methods related to providing safe electrical control and/or communication between a remote controller located in a safe location and interface system for a machine located in a hazardous location. The control and/or communication is provided via industrial-voltage power lines that traverse a barrier separating the safe location from the hazardous location. Control and/or communication is provided by reactively coupling to industrial power lines, which traverse the barrier, so as to superimpose a control and/or communication signal upon AC operating power provided to the machine. Each of the interface system located at the hazardous location and the remote control module located at a safe location provides such reactive coupling to the industrial-voltage power lines so as to communicate therebetween.

A centrifuge for washing magnetic beads in a reaction vessel unit that includes at least one opening, having a housing including an inner surface and a drain, a rotor disposed within the housing, the rotor being configured to hold a reaction vessel unit with its opening(s) directed outwardly toward the inner surface of the housing, a motor coupled with the rotor to rotate around a horizontal rotation axis, and a magnetic element arranged in the rotor to apply a magnetic field to one or more reaction vessels of a reaction vessel unit held by the rotor.

A centrifugal piston according to an embodiment comprises: a piston body defining a path which extends from the front of the piston to the rear of the piston, and through which substances at the front of the piston can move to the rear of the piston; and a valve disposed on the path and configured to selectively open or block the path, wherein, during centrifugation in which centrifugal force acts on the piston, the substances at the front of the piston are centrifuged while the valve is blocking the path, and, when an external force is applied to the piston while the centrifugal force does not act on the piston, the valve moves freely relative to the piston body, and when the valve opens the path, at least a portion of the substances at the front of the piston can move to the rear of the piston.