Provided is a centrifugal member that centrifuges a cell suspension, the centrifugal member including: a cylindrical main body extending in a cylindrical shape in a centrifugal direction, having an inner end wall formed at an inner end in the centrifugal direction, and having an outer end in the centrifugal direction opened; a gasket slidably inserted into an inner portion of the cylindrical main body in the centrifugal direction; a pusher connected to an outer side of the gasket in the centrifugal direction; and a port provided on the inner end wall and communicating with the inner portion of the cylindrical main body.

Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.

Embodiments are directed to methods and apparatuses for ensuring that mechanisms that are used to position components of an apheresis machine are not broken as a result of rotation of a centrifuge. In embodiments, a safety mechanism is provided that contacts components of the centrifuge and pushes them into a position to ensure that they do not break when the centrifuge is operated at high rpm.

Systems and methods are provided for determining and controlling the location of an interface between separated fluid components within a channel of a centrifugal separation chamber being rotated about a rotational axis. Light from a light source is received by a collimator, which directs collimated light through the channel in a direction substantially parallel to the rotational axis. At least a portion of the collimated light exiting the channel is received by a light detector configured as a photodetector array. A signal emitted by the light detector is received by a controller, which determines the location of an interface between separated fluid components within the channel based at least in part on the signal. When the controller determines that the interface is not at a target location within the channel, the controller controls a centrifugal separator and/or a pump system to move the interface to the target location.

A centrifugal separation type FFF device where a rotor can be rotated at a high speed safely so that particles of a smaller size in a sample liquid can be classified. A field flow fractionation device is provided with: a channel that is attached to the inner circumferential surface of the peripheral portion of a rotor and where a classification flow path is created; flow paths for feeding a sample liquid into and out from the classification flow path; and a rotational drive mechanism for rotating the rotational axis, wherein a channel installation portion is formed on one side of the peripheral portion, and a mass balancer portion for adjusting the mass distribution of the rotor is formed on the other side with the rotor base in between.

A collection bottle includes a lid and a canister. The canister has a closed end and an opened end and defines an interior space. The lid includes a lid body having a first side and a second side, a shield handle, and one or more ports. The first side of the lid body is configured to be coupled to the open end of the body to close the interior space. The shield handle and the one or more ports extend from the second side of the lid body. The shield handle extends a first distance from the second side of the lid body. The one or more ports extend a second distance from the second side of the lid body. The first distance is greater than the first distance.

A modular serviceability sled includes a frame, subassembly, interconnection, gasket, and shielding component. The interconnection is operatively connected to the subassembly and includes an electrical, pneumatic, and/or hydraulic connection. The gasket can engage the frame and a base assembly of an apparatus. The shielding component can contact the frame and the base assembly and includes an electromagnetic interference and/or radio frequency shielding component. The sled is movable between an engaged state and a disengaged state. In the engaged state, the sled is at least partially within a receiving space of the apparatus, the gasket engages the frame and the base assembly, the shielding component contacts the frame and the base assembly, and the interconnection is operatively connected to a machine interconnection of the apparatus. In the disengaged state, the interconnection is disconnected from the machine interconnection and the sled is configured to freely move with respect to the base assembly.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A prismatic reflector is provided for incorporation into a centrifugal separation chamber. The prismatic reflector is formed of a light-transmissive material and includes inner and outer walls and first and second end walls. The inner wall is configured to receive light traveling along an initial path and transmit the light to the first end wall, with the first end wall receiving the light transmitted through the inner wall and directing the light toward the second end wall in a direction that is angled with respect to the initial path. The second end wall receives the light from the first end wall and transmits the light out of the prismatic reflector. The initial path of the light may be in a direction toward a rotational axis of the centrifugal separation chamber, with the prismatic reflector redirecting the light into a direction substantially parallel to the rotational axis.