The invention relates to nozzle tips including a nozzle body and a tip portion, configured to minimize the accumulation of a resin on the nozzle tip as it is dispensed through the nozzle tip. The nozzle tip can contain a central flow channel and an internal portion that branches and guides the resin into multiple exiting flow channels that define tangential pathways to the outer surface of the nozzle tip. The nozzle tip can include grooves that define extended, sharply angled flow paths for the resin. Nozzle tips can have a neck portion separating a nozzle body and a tip end of the nozzle tip; here, a doughnut-shaped space located around the neck portion can be defined by the base of the nozzle, the crown of the nozzle, and the neck portion, for encouraging turbulent flow of the resin to scour the nozzle tip during dispensing.

An embodiment provides a nozzle, including: a conical-shaped portion having a first end and a second end substantially opposite the first end, wherein the first end has a smaller diameter than the second end; the first end having an attachment to hold the nozzle in a flow of fluid from an inlet, wherein the nozzle is positioned with the first end facing an inflow of a fluid and the second end facing a chamber; and the conical-shaped portion configured to direct the inflow of the fluid along an inner surface of the chamber, wherein the inflow of the fluid travels around the outer diameter of the conical-shaped portion. Other aspects are described and claimed.

An embodiment provides a nozzle, including: a conical-shaped portion having a first end and a second end substantially opposite the first end, wherein the first end has a smaller diameter than the second end; the first end having an attachment to hold the nozzle in a flow of fluid from an inlet, wherein the nozzle is positioned with the first end facing an inflow of a fluid and the second end facing a chamber; and the conical-shaped portion configured to direct the inflow of the fluid along an inner surface of the chamber, wherein the inflow of the fluid travels around the outer diameter of the conical-shaped portion. Other aspects are described and claimed.

A clamp equipped nozzle for enabling spooling of a hose includes a body defining a lumen having a central axis and configured to enable fluid to flow therethrough. A fluid outlet is in fluid communication with the body and is disposed at a first end of the body. The fluid outlet is configured to enable fluid to flow out of the clamp equipped nozzle defining a flow pattern. A coupler is configured to couple the body to an end of the hose and is disposed at a second end of the body. A clamp is configured to retain a section of the hose and is disposed along a longitudinal portion of the body. The clamp includes walls in a cylindrical configuration, the walls defining a longitudinal length that is approximately parallel the body.

A paint spray nozzle is provided for a paint spray system. The nozzle includes a single-piece body having a conduit portion. The conduit portion includes a first surface defining a first passage that terminates at an orifice along a longitudinal axis and a second surface that defines a second passage along the longitudinal axis. The second passage is fluidly connected to the orifice. The orifice is configured to direct the paint to flow along a flow path through the second passage. The second surface defines an inlet cross-sectional width positioned at the orifice and an outlet cross-sectional width positioned at an outlet. The outlet cross-sectional width is larger than the inlet cross-sectional width, such that the paint that deposits on the second surface is positioned relative to the longitudinal axis to be re-absorbed into the flow path of the paint.

A paint spray nozzle is provided for a paint spray system. The nozzle includes a single-piece body having a conduit portion. The conduit portion includes a first surface defining a first passage that terminates at an orifice along a longitudinal axis and a second surface that defines a second passage along the longitudinal axis. The second passage is fluidly connected to the orifice. The orifice is configured to direct the paint to flow along a flow path through the second passage. The second surface defines an inlet cross-sectional width positioned at the orifice and an outlet cross-sectional width positioned at an outlet. The outlet cross-sectional width is larger than the inlet cross-sectional width, such that the paint that deposits on the second surface is positioned relative to the longitudinal axis to be re-absorbed into the flow path of the paint.

The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.

The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.

The present invention relates to a nozzle for an air trapping device configured to remove air from a fluid, the nozzle comprising a body having an input opening configured to receive the fluid and an output opening configured to distribute the fluid along an edge of the output opening, wherein the edge comprises a control element configured to reduce surface tension of the fluid. The present invention further relates to an air trapping device configured to remove air from a fluid and comprising the nozzle.

The present invention relates to a nozzle for an air trapping device configured to remove air from a fluid, the nozzle comprising a body having an input opening configured to receive the fluid and an output opening configured to distribute the fluid along an edge of the output opening, wherein the edge comprises a control element configured to reduce surface tension of the fluid. The present invention further relates to an air trapping device configured to remove air from a fluid and comprising the nozzle.