A system for dispensing a biocompatible reactive formulation includes a first chamber containing a first fluid having a first reactive component, a second chamber containing a second fluid having a second reactive component, and a third chamber containing a third fluid. A spray tip assembly is configured for spraying a final mixture of the first, second and third fluids. The spray tip assembly has a spray tip housing, a mixing element disposed within the spray tip housing, a mixing chamber located between the mixing element and an inner surface of the spray tip housing. The mixing element has a proximal end adjacent the proximal end of the spray tip housing and a distal end adjacent the distal end of the spray tip housing, a third fluid inlet opening at the proximal end of the mixing element, and one or more third fluid exit openings formed in the outer surface of the mixing element that are in fluid communication with the third fluid inlet opening and that extend laterally to the outer surface of the mixing element for being in fluid communication with the mixing chamber. A fluid connector is secured to the proximal end of the spray tip housing and opposes the proximal end of the mixing element. The fluid connector has first and second fluid channels in fluid communication with the mixing chamber, and a third fluid channel in fluid communication with the third fluid inlet opening of the mixing element. A pump assembly is coupled with the first, second and third chambers for simultaneously forcing the first, second and third fluids to flow through the first, second and third fluid channels of the fluid connector and into the proximal end of the spray tip housing.

An orientation independent delivery device. The delivery device includes a gas chamber, a delivery chamber, a gas cell, and a delivery aperture. The gas chamber includes a gas-side rigid portion and a gas-side flexible barrier. The gas-side flexible barrier is sealed to the gas-side rigid portion. The delivery chamber includes a delivery-side rigid portion and a delivery-side flexible barrier. The delivery-side flexible barrier is sealed to the delivery-side rigid portion and is oriented adjacent to the gas-side flexible barrier. The gas cell is coupled to the gas-side rigid portion of the gas chamber. The gas cell increases a gas pressure within the gas chamber to expand the gas-side flexible barrier. Expansion of the gas-side flexible barrier applies a compressive force to the delivery-side flexible barrier allowing a delivery material to escape from the delivery chamber.

A high pressure capable fluid sprayer includes a piston pump, a main pump housing, and a spray tip. The piston pump has a piston disposed to pump a fluid. The spray tip has an outlet aperture configured to atomize and spray the fluid. The main pump housing is formed of compliant plastic and rated for at least 1600 psi, defines a main pump chamber surrounding the piston, and is disposed to receive fluid from a fluid source.

A high pressure capable fluid sprayer includes a piston pump, a main pump housing, and a spray tip. The piston pump has a piston disposed to pump a fluid. The spray tip has an outlet aperture configured to atomize and spray the fluid. The main pump housing is formed of compliant plastic and rated for at least 1600 psi, defines a main pump chamber surrounding the piston, and is disposed to receive fluid from a fluid source.

A hollow cannula (4) including a perforating tip (5) for perforating a perforating site, said perforating tip (5) being provided with an opening (6), said opening (6) defining a peripheral edge (7) that extends around said opening (6) and that includes a distal axial end and a proximal axial end, said distal axial end of said peripheral edge (7) forming the distal axial end (59) of the perforating tip (5), said distal axial end (59) of the perforating tip (5) being arranged on the longitudinal central axis (A) of said cannula (4), said perforating tip (5) having an outer shape that is rounded in the radial direction, and said distal axial end (59) of said perforating tip (5) being of shape that is rounded in the axial direction.

A hollow cannula (4) including a perforating tip (5) for perforating a perforating site, said perforating tip (5) being provided with an opening (6), said opening (6) defining a peripheral edge (7) that extends around said opening (6) and that includes a distal axial end and a proximal axial end, said distal axial end of said peripheral edge (7) forming the distal axial end (59) of the perforating tip (5), said distal axial end (59) of the perforating tip (5) being arranged on the longitudinal central axis (A) of said cannula (4), said perforating tip (5) having an outer shape that is rounded in the radial direction, and said distal axial end (59) of said perforating tip (5) being of shape that is rounded in the axial direction.

An atomizing nozzle structured particularly for nasal therapy. Preferred embodiments include a 2-piece atomizing nozzle structured to couple with luer-locking structure carried by a syringe. Such an atomizing nozzle includes a nasal stopper and a stem. A preferred nasal stopper includes a distal tip sized for insertion into a nostril of a human child, with a proximal shield portion being structured to resist over-insertion of a discharge orifice into the nostril. A nasal stopper desirably provides a centering function to urge the discharge orifice away from a nasal wall. One operable stem is structured to couple with the stopper and desirably carries unitary thread structure at a proximal end. A second operable stem is structured as a unitary part of the nasal stopper and also desirably carries unitary thread structure at a proximal end. Certain embodiments may also include spacer structure configured to reduce a dead volume inside the atomizing nozzle. Other embodiments may also include spacer structure configured to reduce dead volume inside a syringe that is coupled to the atomizing nozzle.

An atomizing nozzle structured particularly for nasal therapy. Preferred embodiments include a 2-piece atomizing nozzle structured to couple with luer-locking structure carried by a syringe. Such an atomizing nozzle includes a nasal stopper and a stem. A preferred nasal stopper includes a distal tip sized for insertion into a nostril of a human child, with a proximal shield portion being structured to resist over-insertion of a discharge orifice into the nostril. A nasal stopper desirably provides a centering function to urge the discharge orifice away from a nasal wall. One operable stem is structured to couple with the stopper and desirably carries unitary thread structure at a proximal end. A second operable stem is structured as a unitary part of the nasal stopper and also desirably carries unitary thread structure at a proximal end. Certain embodiments may also include spacer structure configured to reduce a dead volume inside the atomizing nozzle. Other embodiments may also include spacer structure configured to reduce dead volume inside a syringe that is coupled to the atomizing nozzle.

A two-component piston for a cartridge includes a piston cover and a piston body. The piston cover has a radially extending attachment portion, a rear side and a front side. The piston body includes a front side and a rear side. The rear side of the piston cover is arranged adjacent to at least a part of the front side of the piston body and includes a valve member configured and arranged to be received within the piston body and to extend into the piston body towards the rear side of the piston body. The piston cover moves relative to the piston body upon actuation of the valve member, and the piston cover is non-releasably connected to the piston body by a part of the piston body being overmolded to the radially extending portion of the attachment portion of the piston cover.

A two-component piston for a cartridge includes a piston cover and a piston body. The piston cover has a radially extending attachment portion, a rear side and a front side. The piston body includes a front side and a rear side. The rear side of the piston cover is arranged adjacent to at least a part of the front side of the piston body and includes a valve member configured and arranged to be received within the piston body and to extend into the piston body towards the rear side of the piston body. The piston cover moves relative to the piston body upon actuation of the valve member, and the piston cover is non-releasably connected to the piston body by a part of the piston body being overmolded to the radially extending portion of the attachment portion of the piston cover.