Disclosed are methods of using focused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Disclosed are methods of using planar or defocused acoustic waves for providing non-invasive sonodynamic therapy. The method includes acoustically coupling an array of piezoelectric transducers to a patient. A controller is configured to generate an electrical drive signal at a frequency selected from a range of frequencies, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce modulated acoustic waves to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Disclosed are methods of producing ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

An ultrasonic transceiver system includes a transmitter block, a receiver block, a state machine, and a computing unit. The transmitter block contains circuitry configured to drive an ultrasound transducer. The receiver block contains circuitry configured to receive signals from the ultrasound transducer and convert the signals into digital data. The state machine is coupled to the transmitter and receiver blocks and contains circuitry configured to act as a controller for those blocks. The computing unit is coupled to the transmitter block, the receiver block, and the state machine and is configured to drive the transmitter block and process data received from the receiver block by executing instructions of a program. The program memory is coupled to the computing unit and is configured to store the program. The computing unit is configured to be reprogrammed with one or more additional programs stored in the program memory.

An ultrasonic transducer device including a substrate, an edge support structure connected to the substrate, and a membrane connected to the edge support structure such that a cavity is defined between the membrane and the substrate, the membrane configured to allow movement at ultrasonic frequencies. The membrane includes a structural layer, a piezoelectric layer having a first surface and a second surface, a first electrode placed on the first surface of the piezoelectric layer, wherein the first electrode is located at the center of the membrane, a second electrode placed on the first surface of the piezoelectric layer, wherein the second electrode is a patterned electrode comprising more than one electrode components that are electrically coupled, and a third electrode coupled to the second surface of the piezoelectric layer and electrically coupled to ground.

Disclosed is a method of generating electrical signal waveforms by a generator. The generator includes a processor and a memory in communication with the processor. The memory defines a first and second table. The processor retrieves information from the first table defined in the memory, where the information is associated with a first wave shape of a first electrical signal waveform for performing a surgical procedure. The processor retrieves information from the second table defined in the memory, where the information is associated with a second wave shape of a second electrical signal waveform for performing a surgical procedure. The processor combines the first and second wave shapes to create a combined wave shape of an electrical signal waveform for performing a surgical procedure and the combined wave shape electrical signal waveform for performing a surgical procedure is delivered to a surgical instrument.

An ultrasonic transceiver system includes a transmitter block, a receiver block, a state machine, a computer unit. The transmitter block contains circuitry configured to drive an ultrasound transducer. The receiver block contains circuitry configured to receive signals from the ultrasound transducer and convert the signals into digital data. The state machine is coupled to the transmitter and receiver blocks and contains circuitry configured to act as a controller for those blocks. The computing unit is coupled to the transmitter block, the receiver block, and the state machine and is configured to drive the transmitter block and process data received from the receiver block by executing instructions of a program. The program memory is coupled to the computing unit and is configured to store the program. The computing unit is configured to be reprogrammed with one or more additional programs stored in the program memory.

An ultrasonic transceiver system includes a transmitter block, a receiver block, a state machine, a computer unit. The transmitter block contains circuitry configured to drive an ultrasound transducer. The receiver block contains circuitry configured to receive signals from the ultrasound transducer and convert the signals into digital data. The state machine is coupled to the transmitter and receiver blocks and contains circuitry configured to act as a controller for those blocks. The computing unit is coupled to the transmitter block, the receiver block, and the state machine and is configured to drive the transmitter block and process data received from the receiver block by executing instructions of a program. The program memory is coupled to the computing unit and is configured to store the program. The computing unit is configured to be reprogrammed with one or more additional programs stored in the program memory.

A method and system for controlling an array of piezoelectric transducers (11, 12, 13). Respective driving signals (Vn) are applied to the transducers. The driving signals (Vn) comprise an alternating component (A) oscillating at one or more driving frequencies to cause corresponding vibrations in the transducers for generating acoustic waves (Wn). One or more of the driving signals (Vn) are offset by a respective bias voltage (Bn). The bias voltage (Bn) is controlled to reduce a difference in resonance frequencies between the transducers. To eliminate any remaining difference, the alternating component (A) to at least a subset of the transducers (11,12) is periodically reset. In this way the phases of the resulting acoustic waves (W1,W2) can be synchronized.

An acoustic device (100) comprises an array of acoustic membranes (1, 2, 3, 4) formed on a foil (10). Each of the acoustic membranes (1, 2, 3, 4) is configured to vibrate ata resonance frequency (Fr) of the acoustic membranes (1, 2, 3, 4) for generating respective acoustic waves (W1,W2,W3,W4). Relative phases (ΔΦ12,ΔΦ34) are determined at which the acoustic membranes (1, 2, 4, 5) are actuated for generating a predetermined interference pattern (C) between the acoustic waves (W1,W2,W3,W4). A lamb wavelength (As) is determined of lamb waves (Ws) at the resonance frequency (Fr) travelling through intermediate sections (lOi, lOj) of the foil between adjacent acoustic membranes (1,2; 3,4). Distances (X12,X34) of the intermediate sections (10i, 10j) between the adjacent acoustic membranes (1,2; 3,4) in the layout are determined in accordance with the relative phases (ΔΦ12,ΔΦ34) and the lamb wavelength for having the lamb waves (Ws), generated by one acoustic membrane (1,3), arrive in phase with an adjacent acoustic membrane (2,4).