The present invention discloses neuro-stimulation systems and methods for affecting cardiovascular function, particularly for improving heart rate variability and treating arrhythmia.

A motion control system includes an actuator having an actuation member, the actuation member having a proximal end attached to the actuator on a first side of a joint and a distal end attached to an anchor element attachment point on a second side of the joint. A first sensor is configured to output signals defining a gait cycle and a second sensor is configured to output signals representing a tensile force in the at least one actuation member. A controller receives the output signals from the sensors and actuates the actuator, during a first portion of the gait cycle, to apply a force greater than a predetermined threshold tensile force to the anchor element attachment point via the actuation member to generate a beneficial moment about the joint and to automatically actuate the actuator.

An improved modular, multi-modal neurostimulation system, includes signal generating, conditioning, and control electronics, stimulation monitoring electronics, and wearable, magnetically coupled energy emitter modules configured for coupling energy emitters to the ear for transcutaneous energy delivery to cranial nerves neurologically accessible in the auricular nerve field. Three energy modalities are available via electrodes for electrical stimulation; optical emitters for electromagnetic stimulation; vibrational emitters for vibrational stimulation. Energy modalities are selectable singularly or in combination. Stimulation control electronics may be integrated within an ear-worn coupling body or located in an external computerized device. Integrated bodily status and biofeedback sensors work with a programmable algorithm to enable closed loop operation based on monitored biofeedback activity, bodily activity and indicia of autonomic functioning. A method for optimizing stimulation using cardiorespiratory feedback and monitoring of divisional indicia of autonomic nervous system function is discussed. Disclosed is a method for optimizing therapeutic interventions via neurostimulation and a method for self-administered neurostimulation and training users in self-administered neurostimulation. Also disclosed is a stimulation coupling apparatus comprising a contour conforming plastic composition for coupling stimulation energy emitters to the auricle of a human being.

An apparatus, system, and method for the regeneration of tissue by pre-tensioning of tissue prior to or in conjunction with the application of mechanotransduction therapy.

Described herein are interactive devices that mimic a portion of a human male and a female genitalia. The male device includes a unique bead drive assembly for providing an extending and retracting motion. Also included on the male device is a massager sub-assembly able to inflate and deflate while being able to slide along a shaft of the male device. The female device includes a clamshell constrictor having an inflation mechanism that is able to provide a squeezing motion as well as being able to slide back and forth within the body of the female device. Also disclosed herein are method of communication and interaction between a pair of interactive devices or multiple interactive devices. Finally, methods of managing interactive sessions between multiple interactive devices are also described.

Described herein are methods for determining a target musculoskeletal activity cycle (MSKC) to cardiac cycle (CC) timing relationship. The method may include detecting a signal responsive to a cyclically-varying arterial blood flow at a location on a head of a user; providing a recurrent prompt at a frequency of the heart pump cycle using the signal, such that the signal correlates with a magnitude of blood flow adjacent to the location, and the recurrent prompt is provided to guide the user to time performance of a component of a rhythmic musculoskeletal activity with the recurrent prompt; and guiding the user to adjust a timing of the component of the rhythmic musculoskeletal activity to substantially maximize a magnitude of the signal. In some embodiments, the method further includes generating the recurrent prompt by amplifying the sound generated by the blood flow in or in proximity to an ear of the user.

In one embodiment, a handheld device for applying therapy includes a housing, a handle coupled to the housing, a motor supported in the housing, a movable head coupled to the motor, and a contact pad of high-friction, grippy, non-slip material supported on the movable head. The motor is operable to impart to the movable head and the contact pad one or more of translational, rotational, or revolutionary motions that are generally in a plane parallel to the skin of a patient during operation.

Embodiments relate to devices, systems and methods of assisting blood flow return to the heart from a limb. The device comprising a wearable garment and a compression apparatus embedded in the garment for applying an external compression to a limb of a user and at least one of a processor or a controller configured to control the compression apparatus to apply the external compression, according to a compression sequence, to a muscle of the limb of the user based on real-time measurements regarding a cardiac cycle having a diastolic phase and systolic phase of the user and real-time measurements of muscle activity. The compression sequence is synchronized to commence when both a local blood flow at the limb is in the diastolic phase and the muscle is in a non-contracted state.

A stimulation system for a wearable article comprises an actuator controllable to deliver a mechanical stimulus to a muscle of a wearer of the article, and one or more electrodiagnostic sensors operable to sense muscle activity from a wearer. The actuator may comprise a structure formed of piezoelectric nanofiber mesh. Also described is a wearable article, a method of delivering a stimulus to a muscle and a method of manufacturing an actuator.

An assistance apparatus includes a first and second wires coupling an upper-body belt and a left knee belt to each other on or above a front and back parts of a body of a user, respectively, a third and fourth wires coupling the upper-body belt and a right knee belt to each other on or above the front and back parts, respectively, a motor, a first sensor that detects at least tensions of the first and third wires, and a control circuit. The control circuit controls the motor to generate, when the first wire is broken, in the second wire, a tension less than a tension of the second wire during no break in the first wire, and to generate, when the third wire is broken, in the fourth wire, a tension less than a tension of the fourth wire during no break in the third wire.