A solids charging containment apparatus and method for mixing a solvent with a dry powder, comprising a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The dual compartment isolator comprises a staging compartment, a charging compartment and a raw material entry port, which is connected to the staging compartment and configured to isolate the dry powder container from the surrounding atmosphere. The mixing vessel includes a mixing chamber and a solids charging port fluidly connecting the mixing chamber to a containment valve in the charging compartment of the dual compartment isolator. The negative cascading pressure controller generates negative pressure in both the staging compartment and the charging compartment. The containment apparatus and method may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing.

A port structure of a containment apparatus is capable of providing a highly reliable port by means of a structure with which a port can be formed in any size at any position and high airtightness thereof can be maintained. The port structure has: a port formation hole that is formed in a transparent synthetic resin sheet defining at least a part of a chamber; an inner ring member disposed on the inner surface side of the port formation hole; an outer ring member disposed on the outer surface side of the port formation hole; and a fastening member that joins the inner ring member and the outer ring member to each other while having a rim portion of the port formation hole held therebetween.

A low-cost drug compounding system that can practically fit inside of a fume hood or the like is provided. The system can use a single pump operable in forward and reverse directions (or multiple pumps) to compound complex mixtures particularly including those requiring the creation of solutions from dry or powdered ingredients. A wireless link allows operation of the system remotely. In one embodiment, the system uses a disposable mixing tube set that can be discarded after mixing while still attached to the base ingredient containers used for the compounding thereby minimize the chance of personnel exposure.

The present invention relates to a device for isolating and cleaning contaminated components comprising a chamber, an entrance door through which components to be isolated and cleaned are introducible into the chamber, means configured to deliver washing solution into the chamber and onto the components to be cleaned, a drying system configured to dry the chamber as well as its content, wherein the device further comprises an exhaust filter system attached to the air exhaust of the chamber, the exhaust filter system comprising a pipe, at least one filter and a blower, the exhaust filter system being configured to be able to bring the chamber under a pressure lower than atmospheric pressure by means of the blower all the time the chamber is closed. The present invention also relates to a corresponding method for isolating and cleaning contaminated components with the aforementioned device.

The disclosure relates to a processing system for in particular pharmaceutical powders, and to a method for decontamination of such a processing system. The processing system includes a processing device for the powder, and a closed housing with an inner production space in which the processing device is arranged. The processing system further includes a steam generator via which water vapor is introduced into the production space in such a quantity that air supersaturated with water vapor develops there at least in some parts. Any powder residues present are bound via water since, on account of the supersaturation, water condenses in the production space. The condensed water, including powder residues bound therein, is removed, in particular with the housing opened.

The present invention provides a work hood that allows for free rotation in a work box to provide a wide work area and easy decontamination of a sealing portion present at the boundary between the work hood and the work box.

A rotation support for rotatably supporting the entire half suit is provided. The rotation support includes a base portion, a rotating portion, a bearing portion, a sealing member, and a communication hole. The base portion is airtightly and annularly provided around an opening, and the rotating portion is provided around the base portion through the bearing portion, with a hem portion of the half suit being fixed to the rotating portion. The sealing member is annularly provided in an annular space formed by the base portion and the rotating portion so as to separate the work box and the external environment. The communication hole is provided so as to lead to the external environmental side from the annular small space side formed by the sealing member together with the base portion, the rotating portion, and the bearing portion, and is connected to a supply means for supplying a decontamination gas and the like to the inside of the small space and to a suction means for sucking clean air and the like from the inside of the small space.

A washing apparatus for a 3D-printed article is provided for the removal of support material from the article. The apparatus includes a glove isolation cabinet with a liquid-discharging nozzle to enable an operator to spray an article with a washing liquid, and a drain. A first filter arrangement receives liquid discharged from the cabinet. The washing liquid drains through the first filter arrangement under the influence of gravity but the first filter arrangement is located in a trough in which washing liquid that has passed through the first filter arrangement accumulates whereby, in use, one or more filters of the first filter arrangement are submerged to ensure filtered-out residue remains submerged in the washing liquid. A pump is provided to pump liquid that has passed through the first filter arrangement through a second filter arrangement adapted to filter out solid material equal to or greater than 5 μm in size.

This invention discloses a decontaminating column for on-line replacing adsorption material, and it includes: a tank having an inner tank being used for filling the adsorption material, and one end of the tank being set to be opened; at least one discharging part is being attached to the tank, and an open-close unit by which the adsorption material can be discharged and which is installed between the discharging part and the tank. There is a chamber in the discharging part, which is connected to a gas replacement unit. At the same time, this invention also discloses a glove box. Compared with the existing technology, this invention effectively solves the problems of low efficiency, high manufacturing cost and high maintenance cost generated by decontaminating column replacement mode in the existing technology; In addition, when the decontaminating column is used in the glove box, replacing the adsorption material can ensure that the water oxygen in the glove box is prevented from leaking out and/or the water oxygen outside of the glove box is prevented from penetrating into the box.

Decontaminating access structures that allow the partial insertion of decontamination tools into glove boxes and the like to easily and safely decontaminate harmful materials are provided.

A containment system and method for creating a confined space around a portion of a piping circuit, and for maintaining the confined space at a designated pressure with a pressurized blanketing gas. The confined spaced with its controlled environment protects against process upsets or icing when insulation is removed from sections in extreme temperature services. The containment system includes a shroud assembly that is made up of a cover configured into a tubular shape, and end plates on axial ends of the cover that mount onto the piping. Support rings are set within the cover that also mount to the pipe, and which provide radial support for the cover along the span between the end plates. Ports are formed through a sidewall of the cover that provide operations personnel access to the piping. Lines carrying the pressurized blanketing gas connect to inlets formed in the cover sidewall.