A method produces a number of medicaments with a predetermined active substance and for simultaneously making an active substance value indicating the active substance quantity contained in the medicament available. A standard value is determined for the active substance quantity of the medicaments and a maximum deviation from the standard value is predefined. An active substance value is selected within an interval cN+/c or predefined and an active substance quantity is used as a reference for the preparation of the respective medicament which quantity matches the active substance value. The active substance value established is associated with the medicament and is held available together with the medicament once the medicament is prepared.

The invention is directed to a method and a device for the dosing of active substances for the preparation of medicaments. In the context of the dosing method, one or more active substances dissolved in a liquid are stored in a storage container, and, in order to permit dosing, a number of drops corresponding to the desired amount of active substance are forced actively through a nozzle onto a substrate or into a collecting vessel; the device used for this purpose comprises at least one storage container for storage of a liquid, and one or more active substances dissolved therein, and also a nozzle through which a number of drops corresponding to the desired amount of active substance are forced out onto a substrate or into a collecting vessel.

In this specification, an expandable structured dosage form for prolonged drug delivery is disclosed. The dosage form comprises a three-dimensional structural framework of physiological fluid-absorptive, drug-containing elements surrounded by interconnected free space. Upon immersing in a physiological fluid, the fluid percolates interconnected free space between elements, and the three-dimensional structural framework expands with fluid absorption and releases drug overtime. The disclosed dosage form enables prolonged delivery of drug into the upper gastrointestinal tract and the blood at a controlled rate for improving the efficacy and safety of drug therapies.

Disclosed is a method for shortening the drying time for drying an encapsulated material including a coating material containing water without causing deformation of the coating when drying. The method employs a fluidized bed dryer for drying coating materials that contain water and that form a coating when the water evaporates. A first drying step involves floating and fluidizing the encapsulated material and limiting a theorisable evaporating water content ?W so that dimples or deformation do not occur in the coating of the encapsulated granular material while measuring a water content or temperature of gas exhausted from the fluidized bed dryer; and a second drying step, performed after the measure water content is reduced below a prescribed amount or the measured temperature has increased, of blowing in gas to the fluidized bed dryer so that the theorisable evaporating water content ?W rises above that during the first drying step.

An apparatus for coating pharmaceutical particles such as drug dosage forms or pellets is provided which includes a drum assembly mounted for rotation about a cylindrical axis of the drum and which includes an outer drum section and an inner perforated drum section mounted concentrically on an interior of the outer drum section such that an annular chamber is formed between the perforated inner drum section and the outer drum section. Two or more baffle plates are attached between an outer surface of the inner perforated drum and an inner surface of the outer drum which are configured to act as baffles to restrain or regulate the flow of air which define two or more compartments depending on the number of baffle plates. One end of the drum assembly includes an end plate with a central aperture for use in loading pellets into the drum and provide access to coating constituents that are pumped into the drum interior during the coating process. An air distribution plate is attached at the other end of the drum and has air flow passageways and is interfaced with an air introduction plate having air inlet and outlet passageways. As the drum rotates the air flow passageways in the distribution plate alternately come into flow communication with the air inlet and outlet passageways in the air introduction plate thereby providing a flow path of air into the perforate inner drum and out of the drum assembly.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present Invention relates to a pellet comprising melatonin and methods of treating insomnia.

A coating apparatus includes an open/close valve having a motor that allows control of opening operation and closing operation in accordance with electric signals applied from a controller. The coating apparatus further includes a suck back valve having a motor that allows control of a volume variation in a flow path for suck back that is in communication with an upstream side and a downstream side of a pipe in accordance with electric signals from the controller. The controller allows control of start of the closing operation of the open/close valve and start of suction operation of the suck back valve through application of the electric signals to the respective motors. This achieves simple adjustment of liquid cut-off.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.