The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.

An authenticable and machine readable coating for pills, tablets and other ingestible materials is provided. The disclosure also relates to methods of authenticating the same. The coatings are formed from a lattice of particles stacked to cause selective diffraction such that each pill or tablet has an optical signature. The signature associated with each coating can be read and authenticated. In one embodiment, the particles are substantially spherical and self-organized. In one embodiment, generally recognized as safe (GRAS) materials are used to form the particles.

A coating apparatus includes an open/close valve having a motor that allows control of opening operation and closing operation in accordance with electric signals applied from a controller. The coating apparatus further includes a suck back valve having a motor that allows control of a volume variation in a flow path for suck back that is in communication with an upstream side and a downstream side of a pipe in accordance with electric signals. The controller allows control of start of the closing operation of the open/close valve and start of suction operation of the suck back valve through application of the electric signals to the motors, respectively. This achieves simple adjustment of liquid cut-off.

A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

A drum coater for applying a surface layer on bulk-like materials includes a rotatably mounted drum for accommodating bulk-like materials, inlet and outlet openings, at least one spray nozzle for applying the surface material, a drying device for a drum interior, at least first and second radially-offset mixing tools in the drum, the first mixing tool protruding into the drum interior. The at least one second mixing tool has at least one mixing surface such that the first mixing tool is at least partially arranged on the drum inner surface and the at least one second mixing tool has at least one opening on the at least one mixing surface. A mixing tool to be used in a drum coater to gently blend and/or homogenize bulk-like materials has a first mixing surface angled relative to a second mixing surface, at least one mixing surface having at least one opening.

Methods for controlling or regulating the volume flow rate of a substance to be sprayed and/or a gas from a nozzle suitable for spraying substances, particularly dispersions, emulsions or suspensions, wherein the nozzle has a nozzle body comprising a nozzle mouthpiece, wherein the nozzle body has an inner pipe, which is connected to a supply for the substance to be sprayed and has an inner wall and a discharge port, and an outer pipe, which is spaced from the inner pipe, is connected to a supply for a gas and has a discharge port, and the discharge port of the inner pipe and the discharge port of the outer pipe are arranged in the region of the nozzle mouthpiece.

The invention relates to a nozzle (101, 201, 301, 401, 501, 601, 701, 801, 901, 1001) for spraying substances, in particular dispersions, emulsions or suspensions.

Please replace the Abstract at page 41 with the following replacement paragraph: A nozzle, for spraying materials, in particular, dispersions, emulsions, or suspensions.

Provided are enrobed gastric residence dosage forms comprising: a gastric residence system in a folded configuration; and a coating enrobing the gastric residence system in the folded configuration, wherein the enrobed gastric residence dosage form is configured to release the gastric residence system in the folded configuration in a stomach of a patient, allowing the gastric residence system to assume an open configuration. The coating comprises water, a plasticizer, a gelling agent, and/or a polymer.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.