This disclosure generally relates to systems and methods for detecting, monitoring, and responding to abnormalities in an infant's breathing. One or more sensing devices may collect infant breathing related data, which may be filtered and converted to a frequency signal. The frequency signal may be monitored for irregularity or stoppage, and a processing module may determine whether the irregularity or stoppage is caused by an actual stoppage or irregularity in infant breathing. If infant breathing is determined to have stopped, a corrective action may be performed.

The drum coater comprises a substantially cylindrical drum (11) with a peripheral wall and a substantially horizontal axis of rotation. The method comprises providing a coating zone within the drum, feeding tablets into the drum, spinning the drum containing the tablets at a rotational speed such that a substantially annular bed of tablets is created, providing means for creating a cascade (19) of tablets at least in a part of the coating zone and spraying the tablets in the coating zone.

Oral dosage forms for the delivery of therapeutic agents include mechanical fasteners for engaging tissue of the gastrointestinal tract.

In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.

A dry powder coating apparatus for coating pharmaceutical solid dosage forms includes a housing; a drum coater; a powder coating system; a liquid spray system; a ventilation system; a heating system; a touch screen control panel; and an operation box. The drum coater may have a truncated cone on both sides, in which one side is opened and another side is closed. The drum coater is horizontally placed inside the operation box along its axis and fixed on a rotatable shaft and a motor drives the rotatable shaft and rotates the drum coater about its own axis.

Providing a mixing apparatus capable of efficiently input noodles coated with an additive to a receiving tray, and having no need to perform weighing again after the noodles are input to the receiving tray.

The mixing apparatus 8 includes: a hopper 30 that houses the falling noodles and that allows noodles to fall while rotating; and a supply device 60 that supplies a sauce to the noodles in the hopper 30, and at least two hopper 30 are provided in a falling direction.

An oral dosage form of a pharmaceutical composition for managing diabetes in a subject is provided, which comprises a core, a controlled membrane film, and an outer film. The core comprises a first antidiabetic agent. The controlled membrane film coats the core tablet and can realize a controlled release of the first antidiabetic agent from the core into a portion of a digestive tract of the subject corresponding to a stomach and an upper gastrointestinal tract after the pharmaceutical composition is orally administered to the subject. The controlled membrane film comprises at least one controlling polymer, each selected from an Eudragit polymer, an Aquacoat polymer, or an Ethocel polymer. The outer film comprises a second antidiabetic agent, and coats the controlled membrane film. A method for manufacturing an oral dosage form of a pharmaceutical composition is also provided.

A tablet measuring apparatus has a stainless steel housing, which contains a measuring section having a conveyance disk and an optical sensor, a tablet feeding section for feeding a tablet to the measuring section, and a recovery section for returning the tablet having undergone a measurement process to a tablet coating apparatus. The optical sensor can be adjusted in its height position by a height adjusting mechanism so that the optical sensor and the tablet can be separated from each other at a predetermined distance. The tablet is sucked to and conveyed by the conveyance disk and, during the conveyance, physical properties of the tablet are measured in a non-contact manner by the optical sensor. Out-of-spec tablets are discharged from a defective product discharging section, while in-spec tablets are fed back to the tablet coating apparatus through the recovery section.

In this specification, a pharmaceutical dosage form comprising a three-dimensional structural framework of thin, solid elements surrounded by interconnected void space is disclosed. The elements comprise at least a drug, a water-absorptive, polymeric excipient, and a hydrophilic surface composition. Upon immersion in a dissolution fluid the three-dimensional structural framework is wetted uniformly, transitions from solid to viscous due to the diffusion of dissolution fluid into the thin elements, expands in all dimensions, and disintegrates and releases drug. The disclosed dosage form enables greater drug delivery rates and better control of the drug concentration in blood for improving the efficacy and safety of drug therapies.

The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.