A cover plate for use in lyophilization processes is provided. The cover plate includes a base portion and a plurality of protuberances which project from the base portion. The protuberances are adapted to fit in one or more delivery containers, such as syringe barrels. The cover plate permits the escape of vapor from the one or more delivery containers during a lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during a lyophilization process. Vent features provided to provide enhanced and preferred venting operations during lyophilization processes.

A cover plate for use in lyophilization processes is provided. The cover plate includes a base portion and a plurality of protuberances which project from the base portion. The protuberances are adapted to fit in one or more delivery containers, such as syringe barrels. The cover plate permits the escape of vapor from the one or more delivery containers during a lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during a lyophilization process. Vent features provided to provide enhanced and preferred venting operations during lyophilization processes.

Described herein are medication-dispensing devices that can comprise mixing and/or entertainment features. These devises are designed to make the experience of taking medication more tolerable for certain classes of individuals that are averse to taking medication, such as small children. In some embodiments, the devices are interactive and configured such that a user can visualize a medication-mixing process or how his or her interaction effects the device. In some embodiments, the devices can comprise a reward-dispensing portion configured to provide a motivational reward for using the device and thus taking a medication. In some embodiments, the medication-dispensing devices comprise features that emit pleasant or exciting sensory output.

The present disclosure provides an apparatus and methods of use for collecting particles. An example collection device includes (a) a vessel defining a chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and (c) an outlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and wherein the outlet port includes a porous material positioned between the chamber and the outlet port.

The present disclosure provides an apparatus and methods of use for collecting particles. An example collection device includes (a) a vessel defining a chamber, wherein the vessel includes a distal end and a proximal end, (b) an inlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and (c) an outlet port extending from the proximal end of the vessel, wherein the inlet port is in fluid communication with the chamber, and wherein the outlet port includes a porous material positioned between the chamber and the outlet port.

The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.

The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm.sup.3 and about 0.15 g/cm.sup.3, and/or a specific surface area (SSA) of at least 18 m.sup.2/g, 20 m.sup.2/g, 25 m.sup.2/g, 30 m.sup.2/g, 32 m.sup.2/g, 34 m.sup.2/g, or 35 m.sup.2/g. Methods for making and using such compositions are also provided.

Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm.sup.3 and about 0.15 g/cm.sup.3, and/or a specific surface area (SSA) of at least 18 m.sup.2/g, 20 m.sup.2/g, 25 m.sup.2/g, 30 m.sup.2/g, 32 m.sup.2/g, 34 m.sup.2/g, or 35 m.sup.2/g. Methods for making and using such compositions are also provided.

The object of the invention is a horizontal paddle dryer that is used for normal or vacuum drying of soaked substances that are in the form of dry powder mixtures or granulates in a manufacturing process and are soaked and mixed (normally with solvents) due to technological needs. Once drying is completed, the interior of the dryer needs to be washed due to various types of substances that differ from each other in content and properties. The construction of the horizontal paddle dryer of the invention allows simple and effective washing of the horizontal paddle dryer without an additional removal of washing heads during the washing of the dryer. The horizontal paddle dryer of the invention has a specially shaped interior wall (1) of the drum (2) that passes on the upper part through two surfaces (1a, 1b) that extend tangentially to the interior wall (1) into a horizontal final surface (1c) of the internal wall (1), such that a slightly concave part is created in the interior of the drum (2) in the wall (1), in which concave part retractable washing heads (3) are arranged that do not hinder functioning of the rotor (4) with paddles (5) either during drying or during washing.