An intelligent dripping pill machine for continuous liquid solidification comprises: a feeding device (1), a material combining device (2), a homogenizing device (3), a dripping device (4) and a de-oiling device (5) sequentially connected via a transmission channel. The intelligent dripping pill machine removes, via high-speed centrifugation, a cooling liquid attached to dripping pills, and each component device is connected compactly, thereby achieving a continuous manufacturing operation, and reducing an occupied space of the devices as a whole while ensuring the yield of the dripping pills.

The present disclosure provides oral drug dosage forms comprising: (a) an erodible non-stimulant material admixed with an ADHD non-stimulant; and (b) an erodible stimulant material admixed with an ADHD stimulant, wherein the erodible non-stimulant material admixed with the ADHD non-stimulant is embedded in a substrate material, and wherein upon exposure to gastrointestinal fluid the ADHD non-stimulant is released according to a desired non-stimulant release profile and the ADHD stimulant is released according to a desired stimulant release profile. In some embodiment, the ADHD non-stimulant is released according to a sustained release profile. In some embodiments, the ADHD stimulant is released according to an immediate release profile. The oral drug dosage forms of the present disclosure are useful for the treatment of attention deficit hyperactivity disorder (ADHD). Also provided herein are methods of designing and manufacturing the oral drug dosage forms described herein.

An embodiment of the present invention provides a manufacturing method of an herbal medicinal tablet formulation for treating obesity which can be prescribed based on Sasang constitutional medicine, comprises manufacturing a concentrated and quantified ephedra powder agent so that an ephedrine content of ephedra, which differs from 0.5-2.5% depending on a producing district and collecting period, is 3.0-4.0%, determining a weight according to each constitution of Sasang constitutional medicine of the concentrated and quantified ephedra powder agent of which the ephedrine content is 3.0-4.0%, and manufacturing a side-effect-preventing powder agent for each constitution to prevent and suppress side effects according to constitution of Sasang constitutional medicine with respect to the weight of the ephedra powder agent, preparing the ephedra powder agent and the side-effect-preventing powder agent while varying a weight ratio therebetween in consideration of weight, obesity, constitution of Sasang constitutional medicine, and side effects while mixing the ephedra powder agent and the side-effect-preventing powder agent; tableting a mixture of the prepared ephedra powder agent and side-effect-preventing powder agent; coating the tableted ones after tableting; and after the coating, while sorting out defective ones from coated ones and packaging, displaying a label including information prepared according to weight, obesity, constitution of Sasang constitutional medicine, and side effects.

An embodiment of the present invention provides a manufacturing method of an herbal medicinal tablet formulation for treating obesity which can be prescribed based on Sasang constitutional medicine, comprises manufacturing a concentrated and quantified ephedra powder agent so that an ephedrine content of ephedra, which differs from 0.5-2.5% depending on a producing district and collecting period, is 3.0-4.0%, determining a weight according to each constitution of Sasang constitutional medicine of the concentrated and quantified ephedra powder agent of which the ephedrine content is 3.0-4.0%, and manufacturing a side-effect-preventing powder agent for each constitution to prevent and suppress side effects according to constitution of Sasang constitutional medicine with respect to the weight of the ephedra powder agent, preparing the ephedra powder agent and the side-effect-preventing powder agent while varying a weight ratio therebetween in consideration of weight, obesity, constitution of Sasang constitutional medicine, and side effects while mixing the ephedra powder agent and the side-effect-preventing powder agent; tableting a mixture of the prepared ephedra powder agent and side-effect-preventing powder agent; coating the tableted ones after tableting; and after the coating, while sorting out defective ones from coated ones and packaging, displaying a label including information prepared according to weight, obesity, constitution of Sasang constitutional medicine, and side effects.

A solid dosage product having a tailored dissolution profile comprises a carrier block defining a plurality of compartments where each respective compartment is configured to receive one or more active pharmaceutical ingredient and the carrier block being digestible within an animal such that each respective active pharmaceutical ingredient is controllably released; and one or more coating layers applied to the carrier block. A method for manufacturing a solid dosage product having a tailored dissolution comprises manufacturing a digestible carrier block where the carrier block defines a plurality of compartments with each respective compartment configured to receive an active pharmaceutical ingredient; filling a respective compartment with a respective active pharmaceutical ingredient; and coating the carrier block with one or more coating layers.

The present disclosure relates to medical devices containing time-release drug substance, and more particularly, to medical tubing, catheters, stents, cables (including fiber optic cables), pills, capsules, sheaths, threads, clamps, sutures, and endotracheal devices. The invention also generally relates to a method for extruding multiple laminated flow streams using microlayer coextrusion to create these various time-release drug delivery products.

The present disclosure relates to medical devices containing time-release drug substance, and more particularly, to medical tubing, catheters, stents, cables (including fiber optic cables), pills, capsules, sheaths, threads, clamps, sutures, and endotracheal devices. The invention also generally relates to a method for extruding multiple laminated flow streams using microlayer coextrusion to create these various time-release drug delivery products.

In an example implementation, a method of producing a diffusion-controlled release device includes accessing diffusion-controlled release input data, and translating the input data into a diffusion-controlled release print file. The method includes executing the diffusion-controlled release print file to control a 3D printing system to produce a diffusion-controlled release device that comprises an active ingredient release profile based on the diffusion-controlled release input data.

In an example implementation, a method of producing a diffusion-controlled release device includes accessing diffusion-controlled release input data, and translating the input data into a diffusion-controlled release print file. The method includes executing the diffusion-controlled release print file to control a 3D printing system to produce a diffusion-controlled release device that comprises an active ingredient release profile based on the diffusion-controlled release input data.

In a method and a corresponding device for producing an extrudate, starting products are introduced into an extrusion container, heated, and homogeneously intermixed by dual asymmetric centrifugation of the extrusion container. The extrusion container is rotated about a primary rotation axis that extends outside the extrusion container, and is simultaneously rotated about a secondary rotation axis that extends through the extrusion container and is situated at an acute angle with respect to the primary rotation axis. Lastly, the intermixed starting products are jointly extruded from the extrusion container. The method and the corresponding device are particularly suitable for processing small and very small substance quantities.