The present invention relates to a capsule filling machine for filling a capsule (20), which comprises an upper capsule part (21) and a lower capsule part (22). Said capsule filling machine comprises a plurality of separate stations for handling the capsules (20) and a capsule separation device (30) and a capsule presence device (40), the capsule separation device (30) and the capsule presence device (40) being integrated into a common station (2).

Technical Problem

A problem of the present invention is, in one aspect, to provide a capsule formulation including an active ingredient and the like that may deteriorate upon contacting an acid, wherein the capsule formulation makes it possible not to deteriorate the active ingredient and the like by a gastric acid which enters into a capsule film.

Technical Solution

A capsule formulation comprising an active ingredient and oil, wherein said capsule of said formulation is an enteric capsule comprising a water soluble film forming polymer and gellan gum; said oil is an oil acceptable for pharmaceuticals or foods; and said active ingredient is encapsulated in said capsule together with said oil, and the production method thereof, are provided.

Technical Problem

A problem of the present invention is, in one aspect, to provide a capsule formulation including an active ingredient and the like that may deteriorate upon contacting an acid, wherein the capsule formulation makes it possible not to deteriorate the active ingredient and the like by a gastric acid which enters into a capsule film.

Technical Solution

A capsule formulation comprising an active ingredient and oil, wherein said capsule of said formulation is an enteric capsule comprising a water soluble film forming polymer and gellan gum; said oil is an oil acceptable for pharmaceuticals or foods; and said active ingredient is encapsulated in said capsule together with said oil, and the production method thereof, are provided.

A tamping assembly for a capsule filling machine is provided. The tamping assembly comprising a dosing disc provided with a plurality of sets of through vertical passages placed substantially equidistantly around the periphery thereof; a bottom plate disposed below the dosing disc, the bottom plate having an open region aligned with a carousel of the capsule filling machine disposed adjacent to the tamping assembly, and a set of apertures aligned with at-least one set of through vertical passages of the dosing disc; a plurality of sets of top tamping plungers disposed above the dosing disc, each set of top tamping plungers configured to be driven downwards for pressing a powdered product in the vertical passages from the top; and at-least one set of bottom tamping plungers disposed below the bottom plate and configured to be driven upwards for pressing the powdered product in the vertical passages from the bottom.

The present invention provides a sonochemical irradiation-based method for the preparation of polydopamine (PDA) nanocapsules having reduced wall thickness and uniform size distribution, which may further comprise at least one payload; nanocapsules obtained by this method; and compositions thereof. Such compositions may be formulated for different purposes, e.g., as pharmaceutical compositions for various therapeutic or diagnostic purposes.

An apparatus for dosing solid particulate material into one or more receptacles, the apparatus comprising: a reservoir for containing an amount of solid particulate material; a dosing unit comprising a dose collection position for collecting a predetermined dose of solid particulate material from the reservoir, and a dose release position for releasing the solid particulate material into the one or more receptacles; a receptacle handling unit for retaining the one or more receptacles, arranged to at least periodically align at least one of the one or more receptacles with the dosing unit when in the dose release position; and optionally a receptacle closing unit for closing the one or more receptacles once filled with the solid particulate material; wherein the dosing unit comprises one or more dosing chambers arranged to displace relative to said reservoir, and/or vice versa, along a perpendicular axis Y such that at least a portion of the chamber(s) is capable of being immerged into, and emerged out of, the solid particulate material at least when the dosing unit is in the dose collection position, the reservoir being arranged to impart a fluid-like state to the solid particulate material at least for the duration of the displacement.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

A weighing system fills capsules with a product, each capsule having a body. The weighing system includes a weighing unit with a weighing cell and a gripping element connected to the weighing cell by means of a loading stem and provided with a housing for receiving and/or retaining a capsule or body to be weighed. The weighing system also includes a connecting element rigidly fixed to the loading stem and slidably and elastically supporting the gripping element that is movable between a measuring position, wherein the gripping element is completely supported by the loading stem and spaced from an abutment wall of the weighing unit by an elastic element, and an end-stroke position reached by contrasting the thrust of the elastic element, wherein the gripping element abuts the abutment wall.

A mass measuring apparatus includes a transferring and gripping device for removing an article from a seat of a movement device, holding the article in a measuring position, and then reinserting the article into the seat. The transferring and gripping device includes a gripping element for holding the article, an actuator for operating with an actuating signal on the gripping element to make the gripping element vibrate at a specific resonance frequency, a sensor for measuring a vibration response signal of the gripping element vibrating and supporting the article in the measuring position, a processing unit for receiving the vibration response signal and controlling the actuator to generate an actuating signal to make the gripping element vibrate at an operating resonance frequency, and then calculating a mass of the article by comparing the operating resonance frequency with the resonance frequency of the gripping element.