A die roll may be used to form soft gel capsules via rotary encapsulation. The die roll may include a plurality of cavities. At least one cavity includes a cavity length, and the die roll includes a first die surface provided along a first portion of the cavity length and a second die surface provided along a second portion of the cavity length. The second die surface may be elevated relative to the first die surface.

A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.

The present invention discloses a closing station (100) for a capsule filling machine comprising a bottom (110) and a top closing unit (120) configured to displace towards each other, such that bottom pins (112) associated with said bottom closing unit urge into through holes of a body holder (B) to contact closed ends of each filled capsule body sections (114) and sliding them into said open ends of each capsule cap sections (124), such that each capsule is partially closed against an exerting pre-compressive force of the top pins (122) and is completely closed when force against biasing means (130) of said top pins (122) is exerted for providing telescoping closing of the cap (124) and body (114) sections of each capsule.

A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multiphase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.

A weighing system is mounted on a support, and the support is configured to support the weighing system. The weighing system includes a feeding mechanism, a conveying and transferring mechanism, pushing rods, a pushing mechanism, resetting mechanisms, a weighing mechanism, and a linkage follower mechanism. The feeding mechanism is arranged at a top portion of the support. The conveying and transferring mechanism is arranged below the feeding mechanism. The conveying and transferring mechanism includes a transferring wheel, a plurality of first channels, a plurality of sliding blocks, a plurality of first grooves and a guide base. The pushing mechanism is arranged on one side of the transferring wheel. The resetting mechanisms are configured to push the sliding blocks connected with the pushing rods to slide along the first channel towards an initial direction, and the weighing mechanism is arranged below the transferring wheel.

A method for producing edible medications comprises providing a three-dimensional (3D) model of the edible medication including an internal cavity sized and shaped for receipt of a medicament therein, printing an edible media to form a portion of the 3D shell corresponding to the model for introduction of the medicament, and then printing the edible media to form the remainder of the 3D shell to completely enclose the medicament within the edible media.

A method for producing edible medications comprises providing a three-dimensional (3D) model of the edible medication including an internal cavity sized and shaped for receipt of a medicament therein, printing an edible media to form a portion of the 3D shell corresponding to the model for introduction of the medicament, and then printing the edible media to form the remainder of the 3D shell to completely enclose the medicament within the edible media.

The disclosure relates to a capsule filling machine for filling two-piece capsules that each include a capsule upper part and a capsule lower part. The capsule filling machine includes a measuring device, the measuring device including a capacitive measuring system. The measuring device is downstream of the closing station. The capacitive measuring system includes a measuring section, along which the mass of the filled, closed capsule can be measured via the capacitive measuring system. The measuring device includes a guide device for the closed capsule, the guide device being configured to convey the filled, closed capsule from the capsule segment to the measuring section of the capacitive measuring system.

Provided is a manufacturing device for a gelatin capsule structured to include a pair of medicinal solution supply units configured to supply medicinal solutions being filled in the capsule while adopting most of structures of an existing manufacturing device for a soft capsule. The device is capable of manufacturing capsules where one capsule is charged with medicinal solutions different from each other, or is capable of increasing productivity compared to the existing manufacturing device.

Provided is a manufacturing device for a gelatin capsule structured to include a pair of medicinal solution supply units configured to supply medicinal solutions being filled in the capsule while adopting most of structures of an existing manufacturing device for a soft capsule. The device is capable of manufacturing capsules where one capsule is charged with medicinal solutions different from each other, or is capable of increasing productivity compared to the existing manufacturing device.