Tamping simulators are provided. The tamping simulator includes a powder cylinder; a dosing receptacle; a tamping pin having a first end and a second end, the tamping pin being configured to be moved between a raised position and a lowered position such that the second end is received into the powder cylinder and the dosing receptacle in an instance in which the tamping pin is in the lowered position; a tamping spring operably coupled to the first end of the tamping pin and being configured to relieve compression pressure from the tamping pin; and a compression scale operably coupled to the tamping spring and being configured to indicate an amount of compression pressure absorbed by the tamping spring.

Items may be packaged for shipping or storage using additive manufacturing techniques, also known as three dimensional (3-D) printing. 3-D printed packaging systems of one or more entities may be transmitted to an aggregator and used for, among other things, optimizing shipping and fulfillment of packages.

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

A method of forming a chemical delivery device with an active chemical includes generating halftoned image data using a stochastic halftone screen a concentration parameter for the active chemical. The method also includes ejecting a chemical carrier including the active chemical into a portion of a plurality of cavities formed in the chemical delivery device using the halftoned image data to produce the chemical delivery device with a concentration of the active chemical corresponding to the concentration parameter.

A method of forming a chemical delivery device with an active chemical includes generating halftoned image data using a stochastic halftone screen a concentration parameter for the active chemical. The method also includes ejecting a chemical carrier including the active chemical into a portion of a plurality of cavities formed in the chemical delivery device using the halftoned image data to produce the chemical delivery device with a concentration of the active chemical corresponding to the concentration parameter.

Disclosed herein are a rotary die encapsulation system and process for manufacturing capsules and uses thereof. The rotary die encapsulation system and process may be used for improving content uniformity of a multi-phase fill composition in a capsule. The rotary die encapsulation system and process may also be used for tuning dose strength of a fill composition in a capsule.

Disclosed herein are a rotary die encapsulation system and process for manufacturing capsules and uses thereof. The rotary die encapsulation system and process may be used for improving content uniformity of a multi-phase fill composition in a capsule. The rotary die encapsulation system and process may also be used for tuning dose strength of a fill composition in a capsule.

A dipping unit for the manufacture of dip-molded dosage form articles comprising: a reservoir for retaining a liquid composition therein; and a flow imparting unit for imparting a flow to said liquid composition, wherein the flow imparting unit is arranged to impart substantially no flow to the liquid composition, at least in a direction perpendicular to a pin dipping axis, when one or more mold pins are dipped in the liquid composition such that each one or more mold pins is exposed to the same flow when dipped in the liquid composition.

A comestible dosage form article for administration to a target subject, the dosage form comprising: an outer capsule comprising a first cap telescopically engageable with a first body; and an inner capsule, within the outer capsule, comprising a second cap telescopically engageable with a second body, wherein the inner capsule is inverted with respect to the outer capsule such that, in an assembled state, the second cap is proximal to the first body and distal to the first cap.