A device for leveling the feeder platform relative to the die table of a tablet compression machine where the device has a base having top surface, a die table engaging surface and a proximate feeder platform surface. The die table surface and the proximate feeder surface are essentially flat and level or parallel with each other. The surfaces are sized such that when mounted on a tablet compression machine, the die table engaging surface is level with and parallel to the die table and the proximate feeder platform surface is approximately parallel to the feeder platform. The proximate feeder platform surface has three or more adjustable sensors attached so that the sensors are in a non-linear arrangement and are level with and parallel to the die table.

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

A system for continuous processing of powder products includes a first inlet configured to input a first dry powder product, a second inlet configured to input a second dry powder product, and a dry powder mixing device that mixes the first dry powder product together with the second dry powder product to form a product mixture. An outlet dispenses the product mixture from the dry powder mixing device. A production machine is included and has a powder feed frame comprising a feed frame inlet connected to the outlet of the dry powder mixing device. The outlet of the dry powder mixing device is positioned at a lower level than the feed frame inlet. A product conveying device is connected between the outlet of the dry powder mixing device and the feed frame inlet to continuously convey the product mixture from the dry powder mixing device to the feed frame inlet.

The invention provides an improved down streaming process for production of polyunsaturated fatty acid salts suitable for tableting by direct compression.

The invention provides an improved down streaming process for production of polyunsaturated fatty acid salts suitable for tableting by direct compression.

The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a) preparing a binder consisting of at least one polyunsaturated fatty acid salt; b) adding the binder and ingredients for the solid dosage form to a mixer; c) optionally carrying out one or more of the following steps: granulation, drying and sizing, d) blending the contents of the mixer; and e) compressing or slugging the blended contents to produce a solid dosage form wherein the binding parameter (BP) for the solid dosage form is at least 2 and is determined by: BP=H/C, wherein H is the tablet breaking force in Newton (N) and C is the compression force in kilo Newton (kN). Solid dosage forms prepared according to this method and the use of PUFA salts as binder in tableting applications for compression of solid components are further comprised by the present invention.

The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a) preparing a binder consisting of at least one polyunsaturated fatty acid salt; b) adding the binder and ingredients for the solid dosage form to a mixer; c) optionally carrying out one or more of the following steps: granulation, drying and sizing, d) blending the contents of the mixer; and e) compressing or slugging the blended contents to produce a solid dosage form wherein the binding parameter (BP) for the solid dosage form is at least 2 and is determined by: BP=H/C, wherein H is the tablet breaking force in Newton (N) and C is the compression force in kilo Newton (kN). Solid dosage forms prepared according to this method and the use of PUFA salts as binder in tableting applications for compression of solid components are further comprised by the present invention.

The present disclosure relates to a method for manufacturing a tablet including (A) filling a starting material, which is in a solid form, in a first open cavity, which is formed by a first punch and a die, to obtain a second open cavity, which is filled at least partly with the starting material, (B) closing the second open cavity by a second punch to obtain a first dosed cavity, (C) compressing the starting material at a compression temperature below 37° C. by moving at least one out of the first punch and the second punch to obtain a second closed cavity, which has a smaller volume than the first closed cavity, which results in formation of a trapped tablet of the starting material in the second closed cavity, (D) removing the trapped tablet to obtain the tablet, which has a tablet temperature below 37° C. directly after removal.

A compression-molding system in which upon a start of a molding machine being stopped, a powdery-material feeding device preliminarily supplies a filling device with a predetermined amount of a powdery material while stopping a relative displacement of the filling device and a compression by an upper punch and a lower punch, and the molding machine is subsequently started to cause the relative displacement of the filling device and the compression by the upper punch and the lower punch.