An oral drug tablet manufacturing device and a manufacturing method thereof comprise a tablet manufacturing area, a micro-control unit, and a collecting area. The tablet manufacturing area comprises a tablet spraying device having a roller and a piezoelectric nozzle, a medicine powder filling container is communicated to the piezoelectric nozzle, the medicine powder filling container contains a plurality of medicine powders, the medicine powders are sprayed and printed through the piezoelectric nozzle, and then the medicine powders are pressed and flattened through the roller to cause the medicine powders to form a drug tablet. The micro-control unit is disposed in the piezoelectric nozzle, the micro-control unit has a storage module and an execution control module. The storage module stores a tablet spray information, the execution control module controls the tablet spraying device through the tablet spray information, and the collecting area is used to collect the drug tablet.

An oral drug tablet manufacturing device and a manufacturing method thereof comprise a tablet manufacturing area, a micro-control unit, and a collecting area. The tablet manufacturing area comprises a tablet spraying device having a roller and a piezoelectric nozzle, a medicine powder filling container is communicated to the piezoelectric nozzle, the medicine powder filling container contains a plurality of medicine powders, the medicine powders are sprayed and printed through the piezoelectric nozzle, and then the medicine powders are pressed and flattened through the roller to cause the medicine powders to form a drug tablet. The micro-control unit is disposed in the piezoelectric nozzle, the micro-control unit has a storage module and an execution control module. The storage module stores a tablet spray information, the execution control module controls the tablet spraying device through the tablet spray information, and the collecting area is used to collect the drug tablet.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Coagglomerates of mannitol, whose laser volume-average diameter D4,3 is between 1 and 200 μm, and of granular starch, are characterized in that they have a disintegration behavior determined according to a test A such that the relaxation time measured is between 30 and 100 seconds and the swelling force is between 0.8 and 3.0 N.

Coagglomerates of mannitol, whose laser volume-average diameter D4,3 is between 1 and 200 μm, and of granular starch, are characterized in that they have a disintegration behavior determined according to a test A such that the relaxation time measured is between 30 and 100 seconds and the swelling force is between 0.8 and 3.0 N.

The invention presented is a die filling apparatus that includes a unique powder feed assembly that includes a novel plurality of vertically stacked drive gear-feed gear pairs that move filling powder through a series of sieves into a die used for compressing powder into a tablet. At least the bottom feed gear includes a plurality of logarithmic vanes or blades with an offset axis of rotation. Also presented is a method to fabricate pellets from powder using an apparatus to form a pellet.

The invention presented is a die filling apparatus that includes a unique powder feed assembly that includes a novel plurality of vertically stacked drive gear-feed gear pairs that move filling powder through a series of sieves into a die used for compressing powder into a tablet. At least the bottom feed gear includes a plurality of logarithmic vanes or blades with an offset axis of rotation. Also presented is a method to fabricate pellets from powder using an apparatus to form a pellet.

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.