The present disclosure provides for a first embodiment, where, a first, lower shaft speed mixing of the component combination takes place in a thermokinetic mixer, where monitoring of the batch by temperature rate increase determination results in a determination that a substantial portion of desired thermokinetic mixing has occurred, whereafter a different shaft speed is used to complete the desired thermokinetic mixing of the component combination.

A solid dosage form for active ingredient release can be a preparation for medical, dental or cosmetic purposes, and is preferably a tablet. The solid dosage form comprises a three-dimensional base body which comprises an active ingredient. The solid dosage form further comprises a portion having a structure forming a two-dimensional identifier, such as, for instance, a QR code.

A filling machine (1) includes a dosing station (3) comprising a supporting element (5) and a dosing unit (10) having a dosing cylinder (12) and a piston (13), for filling bodies (101) of capsule (100) with a product (P) picked-up from a tank (4); the supporting element (5) is movable between a lowered picking position (B), in which the dosing unit (10) is inserted in the tank (4) and a dosing position (C) in which the dosing unit (10) faces a body (101); the piston (13) is movable between a first internal position (D) to form a dosing chamber (15) suitable for picking up and retaining a dose (PI) of product (P), a second internal position (E) to reduce a volume of the dosing chamber (15) and compress the dose (PI) and an external position (F) to push the dose (PI) from the dosing cylinder (12) into a body (101).

A filling machine (1) includes a dosing station (3) comprising a supporting element (5) and a dosing unit (10) having a dosing cylinder (12) and a piston (13), for filling bodies (101) of capsule (100) with a product (P) picked-up from a tank (4); the supporting element (5) is movable between a lowered picking position (B), in which the dosing unit (10) is inserted in the tank (4) and a dosing position (C) in which the dosing unit (10) faces a body (101); the piston (13) is movable between a first internal position (D) to form a dosing chamber (15) suitable for picking up and retaining a dose (PI) of product (P), a second internal position (E) to reduce a volume of the dosing chamber (15) and compress the dose (PI) and an external position (F) to push the dose (PI) from the dosing cylinder (12) into a body (101).

[Object] An object of the present invention is to provide an oral solid preparation that can be produced in a simpler manner than conventional methods, that exhibits high bioavailability and high dissolubility even in persons having low stomach acid, and that can also ensure dissolubility after being allowed to stand for a certain period of time. Another object is to provide a simple method for producing the oral solid preparation.

[Means for Achieving the Object] The present invention relates to an oral solid preparation comprising, as an active ingredient, a finely milled crystal obtained by milling an aripiprazole hydrate crystal, and a pharmaceutically acceptable carrier, the finely milled crystal having a mean particle size of 15 μm or less; and a method for producing an oral solid preparation comprising the steps of (1) milling an aripiprazole hydrate crystal into a finely milled crystal having a mean particle size of 15 μm or less, and (2) mixing the obtained finely milled crystal with a pharmaceutically acceptable carrier.

[Object] An object of the present invention is to provide an oral solid preparation that can be produced in a simpler manner than conventional methods, that exhibits high bioavailability and high dissolubility even in persons having low stomach acid, and that can also ensure dissolubility after being allowed to stand for a certain period of time. Another object is to provide a simple method for producing the oral solid preparation.

[Means for Achieving the Object] The present invention relates to an oral solid preparation comprising, as an active ingredient, a finely milled crystal obtained by milling an aripiprazole hydrate crystal, and a pharmaceutically acceptable carrier, the finely milled crystal having a mean particle size of 15 μm or less; and a method for producing an oral solid preparation comprising the steps of (1) milling an aripiprazole hydrate crystal into a finely milled crystal having a mean particle size of 15 μm or less, and (2) mixing the obtained finely milled crystal with a pharmaceutically acceptable carrier.

In a method and a corresponding device for producing an extrudate, starting products are introduced into an extrusion container, heated, and homogeneously intermixed by dual asymmetric centrifugation of the extrusion container. The extrusion container is rotated about a primary rotation axis that extends outside the extrusion container, and is simultaneously rotated about a secondary rotation axis that extends through the extrusion container and is situated at an acute angle with respect to the primary rotation axis. Lastly, the intermixed starting products are jointly extruded from the extrusion container. The method and the corresponding device are particularly suitable for processing small and very small substance quantities.

A mass measuring apparatus includes a transferring and gripping device for removing an article from a seat of a movement device, holding the article in a measuring position, and then reinserting the article into the seat. The transferring and gripping device includes a gripping element for holding the article, an actuator for operating with an actuating signal on the gripping element to make the gripping element vibrate at a specific resonance frequency, a sensor for measuring a vibration response signal of the gripping element vibrating and supporting the article in the measuring position, a processing unit for receiving the vibration response signal and controlling the actuator to generate an actuating signal to make the gripping element vibrate at an operating resonance frequency, and then calculating a mass of the article by comparing the operating resonance frequency with the resonance frequency of the gripping element.

A mass measuring apparatus includes a transferring and gripping device for removing an article from a seat of a movement device, holding the article in a measuring position, and then reinserting the article into the seat. The transferring and gripping device includes a gripping element for holding the article, an actuator for operating with an actuating signal on the gripping element to make the gripping element vibrate at a specific resonance frequency, a sensor for measuring a vibration response signal of the gripping element vibrating and supporting the article in the measuring position, a processing unit for receiving the vibration response signal and controlling the actuator to generate an actuating signal to make the gripping element vibrate at an operating resonance frequency, and then calculating a mass of the article by comparing the operating resonance frequency with the resonance frequency of the gripping element.

A method for operating a mixing apparatus of a manufacturing plant comprises supplying multiple powdered products to the mixing apparatus. An inlet mass flow rate of the multiple powdered products into the mixing apparatus and a weight of the multiple powdered products in the mixing apparatus are measured. The multiple powdered products in the mixing apparatus are mixed to form a mixed product. The weight of the multiple powdered products in the mixing apparatus and an outlet mass flow rate of the mixed product from the mixing apparatus are predicted based on the measured inlet mass flow of the multiple powdered products. The predicted outlet mass flow rate of the mixed product from the mixing apparatus is corrected based on the measured weight of the multiple powdered products in the mixing apparatus. The mixed product is processed into final products