The invention is directed to a visualizing agent comprising a polyoxazoline molecule and one or more labeling compounds. The visualizing agent can be an ocular staining composition that can be used to stain the vitreous body.

A three-dimensional printing system including a feed source of uncured filled resin material, a print head configured to apply discrete layers of a composition including upconversion phosphors, and a radiation source configured to irradiate layers of uncured filled resin material and deposited layers of the composition is provided. A method of three dimensionally printing a dental article is also provided.

A three-dimensional printing system including a feed source of uncured filled resin material, a print head configured to apply discrete layers of a composition including upconversion phosphors, and a radiation source configured to irradiate layers of uncured filled resin material and deposited layers of the composition is provided. A method of three dimensionally printing a dental article is also provided.

In some aspects, this disclosure relates to compositions and/or methods for identifying or diagnosing dental fractures. In some examples, a composition including a contrast agent is applied to a tooth, and then a diagnostic image of that tooth is obtained. The composition may include barium sulfate and/or radioactive iodine, which may be present in or throughout a dispersion medium facilitating application of the composition to a tooth. The barium sulfate may have a reduced particle size to facilitate dispersion within the medium, and therefore application to a tooth/ligament. The composition may include one or more oils, flavors, dyes, or other additives such as surfactants. The composition may be applied topically or via injection, such as injection into the adjacent periodontal ligament.

In some aspects, this disclosure relates to compositions and/or methods for identifying or diagnosing dental fractures. In some examples, a composition including a contrast agent is applied to a tooth, and then a diagnostic image of that tooth is obtained. The composition may include barium sulfate and/or radioactive iodine, which may be present in or throughout a dispersion medium facilitating application of the composition to a tooth. The barium sulfate may have a reduced particle size to facilitate dispersion within the medium, and therefore application to a tooth/ligament. The composition may include one or more oils, flavors, dyes, or other additives such as surfactants. The composition may be applied topically or via injection, such as injection into the adjacent periodontal ligament.

A method of assessing and/or quantifying remineralization in a tooth model by exposing a tooth model to calcium and a calcium-binding fluorophore either sequentially or simultaneously under conditions sufficient to produce a remineralized/demineralized tooth model; exposing the remineralized/demineralized tooth model to a non-calcium binding fluorophore to produce an enhanced tooth model; and assessing and/or quantifying remineralization, demineralization, or both on the enhanced tooth model by determining the location and extent of calcium binding fluorophore and non-calcium binding fluorophore on the enhanced test tooth sample.

The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralisation developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.

A method of diagnosing optical inhomogeneity of a volume scattering object is provided. The method includes the steps of providing a substance coated with phosphorous materials, adapting the substrate to a surface of a volume scattering object to be diagnosed, and trans-illuminating the volume scattering object with radiation. A dental tool including a substrate is also provided. The substrate includes a transparent flexible film or metallic foil with an applied coating of upconversion phosphors, afterglow particles or both.

The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralization developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.

Compositions are disclosed that simultaneously cleanse, etch, and identifying residual caries during dental restorative procedures, thereby increasing procedure efficiency. Also disclosed are methods describing the use of said compositions in treating subjects as part of dental procedures.