A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

Provided are monomers useful for dental materials that include a compound in which a core and a specific terminal group are bonded to each other directly or via a linking group, wherein the core is a C.sub.1-200 polyvalent organic group having a valence of not less than 3 containing an oxygen atom or a nitrogen atom in which an atom bonded to the terminal group or the linking group is the oxygen atom or the nitrogen atom; the terminal group is a specific (meth)acryloyl group-containing group, a (meth)acryloyl group, a C.sub.1-20 hydrocarbon group or a hydrogen atom, and the terminal group needs to meet specific requirements; and the linking group is a specific divalent group, and when the compound contains a plurality of linking groups, the linking groups may be the same as or different from each other. Compositions, dental materials and kits are also provided.

Provided are monomers useful for dental materials that include a compound in which a core and a specific terminal group are bonded to each other directly or via a linking group, wherein the core is a C.sub.1-200 polyvalent organic group having a valence of not less than 3 containing an oxygen atom or a nitrogen atom in which an atom bonded to the terminal group or the linking group is the oxygen atom or the nitrogen atom; the terminal group is a specific (meth)acryloyl group-containing group, a (meth)acryloyl group, a C.sub.1-20 hydrocarbon group or a hydrogen atom, and the terminal group needs to meet specific requirements; and the linking group is a specific divalent group, and when the compound contains a plurality of linking groups, the linking groups may be the same as or different from each other. Compositions, dental materials and kits are also provided.

The present invention relates to a dental etching composition comprising phosphoric acid, water and urethane-urea compound(s), to the use of said dental etching composition for etching the hard substance of the tooth, to a dental etching composition for use in a therapeutic method of etching the hard substance of the tooth in the course of filling treatment, and to a kit comprising a dental etching composition.

An object of the present invention is to provide a two-paste type dental resin-reinforced glass ionomer cement composition which exhibit high surface curability even under wet conditions, which makes difficult for the surface to become cloudy even if moisture comes in contact with at the initial stage of curing, exhibits high mechanical properties, low water absorption expansion and excellent coloring resistance in the set product and is also excellent in storage stability. The two-paste type dental resin-reinforced glass ionomer cement composition of the present invention consists of two pastes, wherein at least one of the two pastes contains (a) acid-reactive glass powder, (b) polymer of acidic group-containing polymerizable monomer, (c) water, (d) hydroxyl group-containing (meth)acrylate-based polymerizable monomer, (e) tri or more functional (meth)acrylamide-based polymerizable monomer, and (f) polymerization initiator, wherein the paste containing the (c) water does not contain at least one of the (a) acid-reactive glass powder and the (b) polymer of acidic group-containing polymerizable monomer.

An object of the present invention is to provide a two-paste type dental resin-reinforced glass ionomer cement composition which exhibit high surface curability even under wet conditions, which makes difficult for the surface to become cloudy even if moisture comes in contact with at the initial stage of curing, exhibits high mechanical properties, low water absorption expansion and excellent coloring resistance in the set product and is also excellent in storage stability. The two-paste type dental resin-reinforced glass ionomer cement composition of the present invention consists of two pastes, wherein at least one of the two pastes contains (a) acid-reactive glass powder, (b) polymer of acidic group-containing polymerizable monomer, (c) water, (d) hydroxyl group-containing (meth)acrylate-based polymerizable monomer, (e) tri or more functional (meth)acrylamide-based polymerizable monomer, and (f) polymerization initiator, wherein the paste containing the (c) water does not contain at least one of the (a) acid-reactive glass powder and the (b) polymer of acidic group-containing polymerizable monomer.

An object of the present invention is to provide a two-paste type dental resin-reinforced glass ionomer cement composition which exhibit high surface curability even under wet conditions, which makes difficult for the surface to become cloudy even if moisture comes in contact with at the initial stage of curing, exhibits high mechanical properties, low water absorption expansion and excellent coloring resistance in the set product and is also excellent in storage stability. The two-paste type dental resin-reinforced glass ionomer cement composition of the present invention consists of two pastes, wherein at least one of the two pastes contains (a) acid-reactive glass powder, (b) polymer of acidic group-containing polymerizable monomer, (c) water, (d) hydroxyl group-containing (meth)acrylate-based polymerizable monomer, (e) tri or more functional (meth)acrylamide-based polymerizable monomer, and (f) polymerization initiator, wherein the paste containing the (c) water does not contain at least one of the (a) acid-reactive glass powder and the (b) polymer of acidic group-containing polymerizable monomer.

An orthodontic adhesive includes components capable of allowing easy debonding of an orthodontic device from a patient's tooth. The adhesive includes an engineered marine mussel protein. The adhesive may include at least one photocleavable moiety. The adhesive is applied in one or more individual layers. One of the components of the adhesive is capable of binding to a tooth and the other component may be capable of binding to an orthodontic device. A method of adhering an orthodontic device to a tooth includes applying a layer of an orthodontic adhesive to either the tooth or the orthodontic device or the tooth and the orthodontic device and affixing the orthodontic device to the tooth with the orthodontic adhesive situated between the tooth and the orthodontic device. The engineered marine mussel protein includes one or more catechol moieties or one or more derivatives of a catechol moiety.