Provided herein are modified forms of recombinant collagenase polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type recombinant collagenase protein. Further provided are nucleic acid molecules encoding the modified recombinant collagenase polypeptide, compositions including the same and uses thereof in various dental related procedures.

Provided herein are modified forms of recombinant collagenase polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type recombinant collagenase protein. Further provided are nucleic acid molecules encoding the modified recombinant collagenase polypeptide, compositions including the same and uses thereof in various dental related procedures.

A dental composition comprising: a) about 1 to about 80% by weight of particulate material including: (i) calcium silicate, calcium aluminate, tetracalcium aluminoferrite, calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, or mixtures thereof; wherein the particulate material has an average particle size of less than 40 microns; and b) about 1 to about 50% by weight liquid carrier including: (i) water-soluble polymer, and (ii) water.

A dental composition comprising a therapeutically effective amount of doxycycline hyclate and a therapeutically effective amount of triamcinolone acetonide and use in dental treatment.

The invention relates to a monomer mixture for producing a dental material comprising: a. at least one base monomer M1 of the following formula 1: PG-S-A-S[OOCKCOOS-A-S].sub.n-PG (formula 1), where PG=a polymerizable group selected from OOCCHCH.sub.2 and OOCC(CH.sub.3)CH.sub.2; S=a spacer group selected from an unbranched and a branched alkylene, which has C1-C10 carbon atoms and which can also contain oxygen or OOC in the carbon chain, or S is omitted; A=an aliphatic polycyclic group; K=an aliphatic acyclic or cyclic saturated or unsaturated unit with C1-C10 carbon atoms; and n=1-9; b. at least one base monomer M2 of the following formula 2: PGS-ASPG (formula 2), where PG=a polymerizable group selected from OOCCHCH.sub.2 and OOCC(CH.sub.3)CH.sub.2; S=a spacer group selected from an unbranched and a branched alkylene, which has C1-C10 carbon atoms and which can also contain oxygen or OOC in the carbon chain, or S is omitted; and A=an aliphatic polycyclic group, wherein the mass ratio Y=m(M2)/m(M1) of the base monomers M2 to M1 is 0.9Y20. The invention also relates to the use of the monomer mixture, to a polymerizable dental material containing such a monomer mixture, to a polymerizable dental material for use in a therapeutic method, and to a cured dental material.

The invention relates to a monomer mixture for producing a dental material comprising: a. at least one base monomer M1 of the following formula 1: PG-S-A-S[OOCKCOOS-A-S].sub.n-PG (formula 1), where PG=a polymerizable group selected from OOCCHCH.sub.2 and OOCC(CH.sub.3)CH.sub.2; S=a spacer group selected from an unbranched and a branched alkylene, which has C1-C10 carbon atoms and which can also contain oxygen or OOC in the carbon chain, or S is omitted; A=an aliphatic polycyclic group; K=an aliphatic acyclic or cyclic saturated or unsaturated unit with C1-C10 carbon atoms; and n=1-9; b. at least one base monomer M2 of the following formula 2: PGS-ASPG (formula 2), where PG=a polymerizable group selected from OOCCHCH.sub.2 and OOCC(CH.sub.3)CH.sub.2; S=a spacer group selected from an unbranched and a branched alkylene, which has C1-C10 carbon atoms and which can also contain oxygen or OOC in the carbon chain, or S is omitted; and A=an aliphatic polycyclic group, wherein the mass ratio Y=m(M2)/m(M1) of the base monomers M2 to M1 is 0.9Y20. The invention also relates to the use of the monomer mixture, to a polymerizable dental material containing such a monomer mixture, to a polymerizable dental material for use in a therapeutic method, and to a cured dental material.

The invention relates to a dental growth stimulant for regenerating a bone structure, in particular within a tooth pocket, characterized in that the growth stimulant comprises at least a hyaluronic acid or a hyaluronic acid derivative, in particular a hyaluronic acid salt, and wherein the growth stimulant additionally has a calcium compound and/or a zirconium compound.

Methods and systems for using a curable material for endodontic processes are provided. The method comprises using an electroactive composition to cure and optionally un-cure the material. Using an electroactive composition allows for easy introduction of the material without unwanted complexity or side effects. It also allows for easy removal and replacement if desired.

Provided herein compositions including collagenase, and uses thereof in orthodontic procedures, wherein the compositions may include recombinant collagenase and/or modified forms of recombinant collagenase having amino acid(s) truncation or substitutions.

Provided herein compositions including collagenase, and uses thereof in orthodontic procedures, wherein the compositions may include recombinant collagenase and/or modified forms of recombinant collagenase having amino acid(s) truncation or substitutions.