The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent;
wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Topical delivery systems are described. The topical delivery systems include at least one skin care active and nanocellulose in a cosmetic composition. It has been surprisingly found that the presence of nanocellulose in a cosmetic composition enhances or regulates the penetration of skin care actives. The present application further describes a cosmetic composition comprising a skin care active and nanocellulose and use thereof.

The present invention relates to a non-pulverulent cosmetic composition, comprising: (a) at least one lipophilic organic UV filter, and (b) at least one hollow silica sphere particle. The composition according to the present invention can exhibit a good C UV filtering effect.

A method for producing a powder solid composition including a base containing non-volatile liquid oil, the method includes: blending wax in a powder form into the base; dispersing the base in a solvent; volatilizing the solvent at a first temperature where the wax does not dissolve; and heating the base at a second temperature where the wax dissolves, wherein a blending amount of the non-volatile liquid oil is 15% by mass or more and 40% by mass or less with respect to the base.

The present invention provides a nitric-oxide containing composite in the form of microparticles, wherein said microparticles comprise: (i) a core which comprises silica; (ii) a layer on said core which comprises a metal-organic framework; and (iii) nitric oxide;
wherein said metal-organic framework comprises organic ligands comprising at least one amine group, said metal-organic framework is uniformly distributed on the surface of said silica core and said nitric oxide is chemisorbed within said metal-organic framework.

The presently disclosed subject matter relates to a system for customizing a cosmetic product. The system includes: an interface device, in electronic communication with a single batch formulation device. The single batch formulation device is configured to formulate a customized cosmetic product, and a threaded container configured to be imported into the single batch formulation device containing a base and exported from the single batch formulation device containing the customized cosmetic.

Ultraviolet radiation sun protective compositions are reported which feature micronized metal oxide inorganic particles selected from zinc oxide, titanium oxide and mixtures thereof, the inorganic particles being coated with poly[C.sub.8-C.sub.20 hydroxycarboxylic acid], the coated particles measured at a 10% loading in dodecane and 1 minute elapsed time having a Zeta Potential ranging from 2 to 10 mv, amounts of the poly[C.sub.8-C.sub.20 hydroxycarboxylic acid] to the inorganic particles being in a relative weight ratio of 1:100 to 1:10.

Inorganic sunscreen active agents in cosmetic compositions and methods are provided and feature micronized metal oxide inorganic particles selected from the group consisting of zinc oxide, titanium oxide, cerium oxide and mixtures thereof, the inorganic particles being coated with: (i) a poly[C8-C20 hydroxycarboxylic acid], the coated particles measured at a 10% loading in dodecane and at 1 minute elapsed time having a Zeta Potential ranging from 2 to 10 mv, particularly from 2 to 5 mv, amounts of the poly[C8-C20 hydroxycarboxylic acid] to the inorganic particles being in a relative weight ratio of 1:100 to 1:10; or alternatively (ii) an adduct of a hydroxy cinnamate and a silanol, amounts of the adduct to the inorganic particles being in a relative weight ratio of 1:200 to 1:4; or alternatively (iii) mixtures of (i) and (ii).

A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.

The present invention relates to a kit comprising: at least one microneedle sheet (1) comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; and a device comprising an applicator (2-3) comprising an application surface, a container (2-1) comprising a cosmetic composition and a valve, wherein the microneedle sheet (1) is capable being attached to the applicator (2-3) by attaching the substrate layer of the microneedle sheet to the application surface, the applicator (2-3), the container (2-1) and the valve are configured to supply the cosmetic composition via the valve onto the microneedle sheet (1). The kit according to the present invention can prevent the repeated use of microneedles (1), and can apply a cosmetic product in an easy and sanitary manner.