Methods for delivery of a biologic agent to the dermis or superficial muscles by topical application of the agent are provided. The methods comprise, in one embodiment, treating or conditioning a skin area to disrupt the stratum corneum in the skin area to define a treated skin area and applying a formulation comprising a biologic agent to the treated skin area.

The present invention relates to a process for producing a cosmetic article by printing using a laser printer comprising a heating unit and at least one cosmetic toner, the process comprising the steps consisting in: a) producing, with the printer, printing on a support with the aid of the cosmetic toner, b) heating the support coated with the printing with the aid of the heating unit to an operating temperature greater than or equal to 60 C., the cosmetic toner comprising a weight content of material that is fusible at the operating temperature of less than 10% relative to the total weight of the toner.

A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity or the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.

The present invention relates to an artificial cell membrane system comprising at least one membrane protein carrier associated with at least one membrane protein, wherein the at least one membrane protein carrier comprises or consists of a polymeric vesicle or a polymeric planar structure, and a solid support freely suspended in a fluid medium, wherein the at least one membrane protein carrier is attached to a surface of the solid support. A method of forming the artificial cell membrane system, and use of the artificial cell membrane system as a reagent are also provided.

The invention relates to mixtures having: components (a) having at least one fragrance of the formula (I) ##STR00001## where R1=OCR2, CH.sub.2OR3, C1-C8 open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, with R2=an open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, having 2-10 C atoms, with R3=an open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, having 1-8 C atoms, and components (b) having at least one fragrance, different from the fragrances of component a,
characterized in that the weight ratio of all components (a) to all components (b) is from 1:10 to 1:10000.

The present invention provides an oral care composition comprising: (a) a metal salt of pyrrolidone carboxylic acid; (b) at least one fluoride ion source; and (c) at least one a-hydroxy acid or salt thereof; wherein the composition is a mouthwash or a mouthrinse.

The present invention provides an oral care composition comprising: (a) a metal salt of pyrrolidone carboxylic acid; (b) at least one fluoride ion source; and (c) at least one a-hydroxy acid or salt thereof; wherein the composition is a mouthwash or a mouthrinse.

Systems, methods, and computer-readable media for a color reproduction service are provided.

Provided is an oral care composition, e.g., a dentifrice, comprising a calcium abrasive, e.g., calcium carbonate, potassium nitrate (KNO3), and a basic amino acid, in free or salt form, e.g., arginine, in free or salt form, wherein the potassium nitrate is present in an amount of 0.1-1% by weight of the composition and methods of using the same.

New systems, devices and methods for testing, analyzing and managing skin and skin microbiomes are provided. According to some embodiments, a skin and skin microbiome testing and management system is provided, including at least one computer hardware- and software-based control system and a wand device with rapidly replaceable testing and application cartridges comprising rollers. In some embodiments, the control system enrolls user(s) and issues testing kits to the user(s), including the specialized wand device, testing substrates and reagents. In some embodiments, techniques for sampling and testing a skin microbiome are set forth. Further techniques for analyzing skin conditions, based on the results of that testing, and issuing management techniques based on those results, are also provided.