Methods for delivery of a biologic agent to the dermis or superficial muscles by topical application of the agent are provided. The methods comprise, in one embodiment, treating or conditioning a skin area to disrupt the stratum corneum in the skin area to define a treated skin area and applying a formulation comprising a biologic agent to the treated skin area.

Methods for delivery of a biologic agent to the dermis or superficial muscles by topical application of the agent are provided. The methods comprise, in one embodiment, treating or conditioning a skin area to disrupt the stratum corneum in the skin area to define a treated skin area and applying a formulation comprising a biologic agent to the treated skin area.

The present invention provides an oral care composition comprising: (a) a metal salt of pyrrolidone carboxylic acid; (b)at least one fluoride ion source; and (c) at least one α-hydroxy acid or salt thereof; wherein the composition is a mouthwash or a mouthrinse.

The present disclosure relates to detergents and cleaning agents comprising at least one protease and at least one organic compound of the formula (I) which acts as a protease inhibitor and therefore is a suitable enzyme stabilizer, and to the use of said compounds as enzyme stabilizers in protease-containing detergents and cleaning agents. The present disclosure also relates to the corresponding washing and cleaning methods and to the use of the detergents and cleaning agents.

The disclosure provides hypersensitivity preventative tooth varnish compositions comprising, inter alia, ethyl cellulose and fluoride, and methods for the use of such compositions for the treatment of hypersensitive teeth.

The disclosure provides hypersensitivity preventative tooth varnish compositions comprising, inter alia, ethyl cellulose and fluoride, and methods for the use of such compositions for the treatment of hypersensitive teeth.

Hydrogel particles are provided that include a crosslinked polymer and a drug conjugated to the crosslinked polymer. The hydrogel particles may include a pH sensitive moiety and a redox sensitive moiety. The hydrogel particles also may be dispersed in a host hydrogel. Kits and methods of drug delivery and treatment also are provided.

Hydrogel particles are provided that include a crosslinked polymer and a drug conjugated to the crosslinked polymer. The hydrogel particles may include a pH sensitive moiety and a redox sensitive moiety. The hydrogel particles also may be dispersed in a host hydrogel. Kits and methods of drug delivery and treatment also are provided.

A topical skin product having a retention property is provided. The topical skin product comprises a retention ingredient. A suitable retention ingredient is an oxazoline homopolymer or an extended or a modified polymer based on an oxazoline homopolymer. The topical skin product may be a hand sanitizer having a gel-based hand sanitization formulation.

A topical skin product having a retention property is provided. The topical skin product comprises a retention ingredient. A suitable retention ingredient is an oxazoline homopolymer or an extended or a modified polymer based on an oxazoline homopolymer. The topical skin product may be a hand sanitizer having a gel-based hand sanitization formulation.