A soothing lip balm composition includes a wax binder component, which includes at least two compounds selected from a C.sub.8-C.sub.30 fatty acid, esterified C.sub.8-C.sub.30 fatty acid, and C.sub.8-C.sub.30 fatty alcohols; a complex fat component, which includes at least three different compounds selected from C.sub.8-C.sub.30 fatty acids; an organic compound component, which includes at least three compounds selected from 2,5-dimethoxy-p-cymene, cumene, thymol methyl ether, 2,6-diisopropylanisole, decanal, and 1,2,2,3-tetramethylcyclopent-3-enol; and an enzymatic component, which includes cysteine endopeptidase.

A soothing lip balm composition includes a wax binder component, which includes at least two compounds selected from a C.sub.8-C.sub.30 fatty acid, esterified C.sub.8-C.sub.30 fatty acid, and C.sub.8-C.sub.30 fatty alcohols; a complex fat component, which includes at least three different compounds selected from C.sub.8-C.sub.30 fatty acids; an organic compound component, which includes at least three compounds selected from 2,5-dimethoxy-p-cymene, cumene, thymol methyl ether, 2,6-diisopropylanisole, decanal, and 1,2,2,3-tetramethylcyclopent-3-enol; and an enzymatic component, which includes cysteine endopeptidase.

The present invention relates to a hydrogel formulation for delivering probiotics including a hydrogel, probiotics and zwitterionic buffer as an active ingredient, a composition for delivering probiotics comprising the same and a method of preparing the same, which adjust and maintain the internal pH of the hydrogel even in the gastric juice environment, thereby increasing the survival rate of the probiotics in the gastric juice and improving the delivery rate to the large intestine, by further adding zwitterionic buffer capable of maintaining pH to the hydrogel encapsulated with probiotics.

The present invention relates to a hydrogel formulation for delivering probiotics including a hydrogel, probiotics and zwitterionic buffer as an active ingredient, a composition for delivering probiotics comprising the same and a method of preparing the same, which adjust and maintain the internal pH of the hydrogel even in the gastric juice environment, thereby increasing the survival rate of the probiotics in the gastric juice and improving the delivery rate to the large intestine, by further adding zwitterionic buffer capable of maintaining pH to the hydrogel encapsulated with probiotics.

The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

The present invention provides a black plaster producing device that comprises a workbench, longitudinal supports, a transverse bottom plate, an electric-heated thermostatic drying oven, and a storage rack structure for classified storage, a storage bucket, a stove, a boiling furnace, a furnace cover, a stirring box, a box cover, a stirring motor, a stirring pipe, a crushing blade, an adjustable partition frame structure, a rolling frame structure, a gas inlet pipe, a pipe valve, a stirring switch, a rolling switch and a receiving bucket, wherein the longitudinal supports are welded at four corners at the lower part of the workbench respectively, and the transverse bottom plate is screwed at the lower part of the longitudinal supports on the inner side. The transverse partition plate of the present invention is screwed at the central position inside the storage box, which facilitates the convenient storage of materials in the storage box during use and can classify the stored materials at the same time. The semiconductor refrigerating chip is screwed on the rear side of the inner wall at the lower part of the storage box, which facilitates the refrigeration and preservation of the materials stored at the bottom of the storage box on the inner side during use.

The present invention provides a black plaster producing device that comprises a workbench, longitudinal supports, a transverse bottom plate, an electric-heated thermostatic drying oven, and a storage rack structure for classified storage, a storage bucket, a stove, a boiling furnace, a furnace cover, a stirring box, a box cover, a stirring motor, a stirring pipe, a crushing blade, an adjustable partition frame structure, a rolling frame structure, a gas inlet pipe, a pipe valve, a stirring switch, a rolling switch and a receiving bucket, wherein the longitudinal supports are welded at four corners at the lower part of the workbench respectively, and the transverse bottom plate is screwed at the lower part of the longitudinal supports on the inner side. The transverse partition plate of the present invention is screwed at the central position inside the storage box, which facilitates the convenient storage of materials in the storage box during use and can classify the stored materials at the same time. The semiconductor refrigerating chip is screwed on the rear side of the inner wall at the lower part of the storage box, which facilitates the refrigeration and preservation of the materials stored at the bottom of the storage box on the inner side during use.

Dental treatments and methods, including treating gum disease, using peroxide gel and a viscous antibacterial agent including tetracycline to chemically debride and curettage a treatment area. Treatments and methods include non-surgically scaling and root plaining the treatment area with dental tools such as periodontal scalers and/or curettes during the active period of the chemical debridement. The working surfaces of dental tools can be sharpened for optimal root and tooth surfacing during treatment. Treatment can include instructions for co-therapy by or on behalf of treatment subjects between visits and for maintenance care.

Dental treatments and methods, including treating gum disease, using peroxide gel and a viscous antibacterial agent including tetracycline to chemically debride and curettage a treatment area. Treatments and methods include non-surgically scaling and root plaining the treatment area with dental tools such as periodontal scalers and/or curettes during the active period of the chemical debridement. The working surfaces of dental tools can be sharpened for optimal root and tooth surfacing during treatment. Treatment can include instructions for co-therapy by or on behalf of treatment subjects between visits and for maintenance care.

This disclosure relates to methods of reducing itch in patients with atopic dermatitis and treating patients with atopic dermatitis by administering a topical 0.75% or 1.5% ruxolitinib cream two times per day.