[Object] To provide fine particles 2 having good printing characteristics, good thermal conductivity, and good electrical conductivity.

[Solution] The fine particles 2 are flake-like. A main component of the fine particles 2 is an electrically conductive metal. A typical metal is silver. A particle diameter D50 of particles including a large number of the fine particles 2 is equal to or greater than 0.10 μm but equal to or less than 0.50 μm, a particle diameter D95 of the particles is equal to or less than 1.00 μm, and a maximum particle diameter Dmax of the particles is equal to or less than 3.00 μm. A particle diameter D10 of the particles is equal to or greater than 0.05 μm. A BET specific surface area of the particles is equal to or greater than 2.0 m.sup.2/g. A tap density TD of the particles is equal to or greater than 2.0 g/cm.sup.3. An average Tave of thicknesses of the fine particles 2 is equal to or less than 0.05 μm.

The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.

The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.

There is disclosed an article which is formed of a solid-phase or liquid-phase sintered product of a metal powder, ceramic powder or glass powder. For manufacturing the article, an extrudable mixture which contains the material powder and a thermoplastic binder is shaped into a continuous filament suitable for use in fused filament 3D printers. The printed object is then invested in plaster or other castable refractory. The invested object is then subjected to heating. The heating process burns off the thermoplastic binder and sinters the powders of metal, glass or ceramic, leaving a pure metal, glass or ceramic object.

The extrudable mixture is produced by preparing a material powder, preparing thermoplastic binder, blending the material powder and the thermoplastic binder together. The most preferable extrudable mixture contains 80 to 92% by weight of metal powder, 8 to 20% by weight of thermoplastic binder, and 0.0 to 0.1% unavoidable impurities. The extrudable mixture is then extruded into a continuous filament suitable for use in various 3d printing hardware.

A manufacturing method for a bonded magnet, in particular a manufacturing method for an anisotropic bonded magnet. The present invention solves the problem that the existing manufacturing method under the condition of heating magnetic powders performs magnetic field orientation after a binder is melted, resulting in low production efficiency, a complicated mould structure, high process costs, thereby affecting wide use of an anisotropic bonded magnet. A manufacturing method for an anisotropic bonded magnet comprising the following steps: 1) mixing anisotropic magnetic powders and a thermosetting binder; 2) adding the mixture of step 1) to a mould cavity, performing pressure forming under an oriented magnetic field, and performing demagnetization, so as to obtain a green body; and 3) loading the green body of step 2) into a vacuum furnace for thermal curing, so as to obtain an anisotropic bonded magnet. In the present application, forming is performed in a magnetic field at normal temperature or in a cold state, avoiding magnetic powders being bonded to each other, improving the effect of magnetic field orientation, and the mould has a simple structure, is easy to operate, and provides high efficiency, thereby lowering cost.

A magnetic core has a structure in which Fe-based soft magnetic alloy particles are connected via a grain boundary. The Fe-based soft magnetic alloy particles contain Al, Cr and Si. An oxide layer containing at least Fe, Al, Cr and Si is formed at the grain boundary that connects the neighboring Fe-based soft magnetic alloy particles. The oxide layer contains an amount of Al larger than that in Fe-based soft magnetic alloy particles, and includes a first region in which the ratio of Al is higher than the ratio of each of Fe, Cr and Si to the sum of Fe, Cr, Al and Si, and a second region in which the ratio of Fe is higher than the ratio of each of Al, Cr and Si to the sum of Fe, Cr, Al and Si. The first region is on the Fe-based soft magnetic alloy particle side.

The present invention provides a silver coating composition that develops excellent conductivity (low resistance value) by low-temperature and short-time calcining, and that is excellent in fine-line drawing performance and suitable for intaglio offset printing. A silver particle coating composition comprising: silver nano-particles (N) whose surfaces are coated with a protective agent containing an aliphatic hydrocarbon amine; a surface energy modifier; and a dispersion solvent. The surface energy modifier may be selected from the group consisting of a silicon-based surface energy modifier and an acrylic surface energy modifier. The coating composition preferably further comprises silver microparticles (M). The silver coating composition is suitable for intaglio offset printing.

One aspect of the present invention is a lubricant to be incorporated into a powder metallurgical mixed powder containing an iron-based powder. The lubricant includes a flaky organic material having an average particle diameter of from 0.1 μm to less than 3 μm. Another aspect of the present invention is a powder metallurgical mixed powder which contains an iron-based powder and the lubricant. Yet another aspect of the present invention is a method for producing a sintered compact. The method includes the step of mixing materials to give a powder metallurgical mixed powder containing an iron-based powder and the lubricant. The powder metallurgical mixed powder is compacted using a die to give a powder compact. The powder compact is sintered to give a sintered compact.

A system for metal injection and counter pressure has: a particle providing assembly; and a forming unit having a melting module, a counter pressure module and a mold module; wherein, the particle providing assembly provides particles with metal powder and a binding agent to the melting module, the particles is formed into melted flow by the melting module, the melted flow is provided to the mold module, the counter pressure module provides a counter gas with predetermined pressure to the mold module, the melted flow forms into a green part inside of the mold module.

A system for metal injection and counter pressure has: a particle providing assembly; and a forming unit having a melting module, a counter pressure module and a mold module; wherein, the particle providing assembly provides particles with metal powder and a binding agent to the melting module, the particles is formed into melted flow by the melting module, the melted flow is provided to the mold module, the counter pressure module provides a counter gas with predetermined pressure to the mold module, the melted flow forms into a green part inside of the mold module.