Provided are methods of diminishing the signs of aging and/or improving the health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention comprise a peptide comprising the sequence selected from LRLK (SEQ ID NO: 1), MVV (SEQ ID NO: 2), TAKDGAP (SEQ ID NO: 3), IFGGTVYRS (SEQ ID NO: 4), and RTPKISKPIKFELSG (SEQ ID NO: 5) or a derivative, or fragment thereof, in a topically acceptable vehicle.

An active constituent complex includes an active carrier, an anti-inflammatory agent, a collagen synthesis enhancer, an anti-wrinkle agent, and a keratinocyte growth factor stimulant. The active constituent complex may be incorporated into a skincare composition, such as for topical application to human skin, for promoting skin repair and restructure, and for treating skin conditions.

An active constituent complex includes an active carrier, an anti-inflammatory agent, a collagen synthesis enhancer, an anti-wrinkle agent, and a keratinocyte growth factor stimulant. The active constituent complex may be incorporated into a skincare composition, such as for topical application to human skin, for promoting skin repair and restructure, and for treating skin conditions.

Prior art describes methods for making whole-plant extracts from the Cannabis plant. Terpenes and cannabinoids are classes of compounds found inherently in those extracts. But, because those extracts contain hundreds of different, and sometimes counteracting, compounds, they are not the most effective treatments for common health issues. Specific terpenes and cannabinoids may be isolated and chosen for their use for specific conditions. Examples of the present invention differ from the prior art by selecting isolated compounds (Like the cannabinoid THC and the terpene Myrcene) and specifically combining them with essential and topical agents to produce targeted treatments.

Prior art describes methods for making whole-plant extracts from the Cannabis plant. Terpenes and cannabinoids are classes of compounds found inherently in those extracts. But, because those extracts contain hundreds of different, and sometimes counteracting, compounds, they are not the most effective treatments for common health issues. Specific terpenes and cannabinoids may be isolated and chosen for their use for specific conditions. Examples of the present invention differ from the prior art by selecting isolated compounds (Like the cannabinoid THC and the terpene Myrcene) and specifically combining them with essential and topical agents to produce targeted treatments.

Prior art describes methods for making whole-plant extracts from the Cannabis plant. Terpenes and cannabinoids are classes of compounds found inherently in those extracts. But, because those extracts contain hundreds of different, and sometimes counteracting, compounds, they are not the most effective treatments for common health issues. Specific terpenes and cannabinoids may be isolated and chosen for their use for specific conditions. Examples of the present invention differ from the prior art by selecting isolated compounds (Like the cannabinoid THC and the terpene Myrcene) and specifically combining them with essential and topical agents to produce targeted treatments.

The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.

The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.

The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.

The present invention relates to a novel use of sesquiterpenoid compounds, the pharmaceutically acceptable salts thereof, or the extracts of Cyperus rotundus comprising same or the fractions thereof in the prevention or treatment of menopausal diseases. The sesquiterpenoid compound according to the present invention, the extracts of Cyperus rotundus comprising the same or fractions thereof exhibit excellent estrogenic activity or anti-allergic activity, and therefore they can be used for the prevention or treatment of menopausal diseases caused by a decline in estrogen level or by allergic diseases.