Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

The solution provides a method for separating a Chinese traditional medicine composition. To explain a pharmacological effect mechanism of a medicine made of two or more components and scientific content in rules of compatibility among components of a compound medicine, systematic researches on the material basis is very necessary. Accordingly, deep researches are done on chemical components of the pharmaceutical composition in the solution, and eight compounds are separated, which are 10-O-(p-hydroxycinnamoyl)-adoxosidic acid, aloe-emodin-8-O-β-D-glucopyranoside, quercitrin, matairesinol-4′-O-glucoside, liquiritin apioside, epi-vogeloside, vogeloside and ethyl caffeate, which provides a new quality control method for the composition in the solution.

The present invention relates to an easy to administer topical lip balm/ointment composition for quickly healing fever blisters caused by the HSV-1 virus. The lip balm/ointment is topically applied to an affected area using a fingertip, or rolling a composition stick, and is penetrated deep into the skin for blocking the virus and protecting healthy skin cells. The composition includes a unique formulation of natural and organic ingredients consisting of beeswax, shea butter, liquid coconut oil, organic lemon or peppermint flavor, menthol, and colloidal silver. The composition heals the cold sore within 48 hours without using any harmful chemicals available in over-the-counter pharmacy products. The composition is available in small containers or rolling sticks.

The present invention relates to an easy to administer topical lip balm/ointment composition for quickly healing fever blisters caused by the HSV-1 virus. The lip balm/ointment is topically applied to an affected area using a fingertip, or rolling a composition stick, and is penetrated deep into the skin for blocking the virus and protecting healthy skin cells. The composition includes a unique formulation of natural and organic ingredients consisting of beeswax, shea butter, liquid coconut oil, organic lemon or peppermint flavor, menthol, and colloidal silver. The composition heals the cold sore within 48 hours without using any harmful chemicals available in over-the-counter pharmacy products. The composition is available in small containers or rolling sticks.

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

The present invention relates to the use of mono- and bis nitrosylated propanediols, and compositions and formulations comprising the same, in methods for the treatment of a microbial infection.

The present invention relates to the use of mono- and bis nitrosylated propanediols, and compositions and formulations comprising the same, in methods for the treatment of a microbial infection.

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.