The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

The present invention features a method for reducing the damage caused by free radicals, the method comprises administering a pharmaceutical composition that comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier to a subject. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.

The present invention features a method for reducing the damage caused by free radicals, the method comprises administering a pharmaceutical composition that comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier to a subject. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.

Provided herein is a method of promoting wound healing in a subject, comprising administering to the subject a polyphenol. Also provided herein is a method of treating a wound in a subject, comprising administering to the subject a polyphenol.

Provided herein is a method of promoting wound healing in a subject, comprising administering to the subject a polyphenol. Also provided herein is a method of treating a wound in a subject, comprising administering to the subject a polyphenol.

Provided herein is a method of promoting wound healing in a subject, comprising administering to the subject a polyphenol. Also provided herein is a method of treating a wound in a subject, comprising administering to the subject a polyphenol.

The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I:
F.sub.1-X.sub.1-L.sub.1-X.sub.2-P.sub.1-X.sub.3-G.sub.1  (Formula I)
The invention relates to the treatment of diseases or disorders mediated by ARID1A (BAF250A).

The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention further relates to compounds of Formula I:
F.sub.1-X.sub.1-L.sub.1-X.sub.2-P.sub.1-X.sub.3-G.sub.1  (Formula I)
The invention relates to the treatment of diseases or disorders mediated by ARID1A (BAF250A).

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.