The presently claimed invention is related to compositions and methods for treating H.sub.2S related diseases comprising administering a pharmacologically effective amount of pharmaceutical composition containing a first therapeutic, wherein the first therapeutic includes one of an ATR kinase inhibitor and an ATR kinase promotor. According to further embodiments the H.sub.2S related disease is one of cancer, cardiovascular disease, acute inflammation, chronic inflammation, and neurological disease.

The presently claimed invention is related to compositions and methods for treating H.sub.2S related diseases comprising administering a pharmacologically effective amount of pharmaceutical composition containing a first therapeutic, wherein the first therapeutic includes one of an ATR kinase inhibitor and an ATR kinase promotor. According to further embodiments the H.sub.2S related disease is one of cancer, cardiovascular disease, acute inflammation, chronic inflammation, and neurological disease.

Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at ≥ about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a low molecular weight organic compound in an inert gas stream are also provided.

Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at ≥ about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a low molecular weight organic compound in an inert gas stream are also provided.

In a method of treating a patient having low blood flow that may be caused by diffused plaque and/or a plaque mass associated with Peyronie's disease in a penile region, a predetermined amount of carbon dioxide is injected into affected corpus cavernosum at a location that is adjacent to, but spaced away from the plaque mass. In addition, either before and/or after the injection of the carbon dioxide, a decalcifying agent(s) may be injected directly into the plaque mass.

In a method of treating a patient having low blood flow that may be caused by diffused plaque and/or a plaque mass associated with Peyronie's disease in a penile region, a predetermined amount of carbon dioxide is injected into affected corpus cavernosum at a location that is adjacent to, but spaced away from the plaque mass. In addition, either before and/or after the injection of the carbon dioxide, a decalcifying agent(s) may be injected directly into the plaque mass.

The present invention provides compositions and methods for increasing nitric oxide production for treating or preventing a chronic inflammatory autoimmune disease or disorder.

The present invention provides compositions and methods for increasing nitric oxide production for treating or preventing a chronic inflammatory autoimmune disease or disorder.

Described herein are novel γ- and δ-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.

Described herein are novel γ- and δ-propargyl carboxylic acids and esters. The novel compositions are antagonists of CSE and may be used to modulate of the activity of the carotid body, therefore providing therapeutic benefits for sleep-related breathing disorders and related conditions.