The present invention relates to a transdermal therapeutic system for the transdermal administration of an active agent comprising an active agent-containing layer structure, said active agent-containing layer structure comprising: A) a backing layer; B) an active agent-containing layer comprising at least one acrylic polymer; C) a skin contact layer; and wherein the skin contact layer is an adhesive layer comprising a silicone gel adhesive.

The disclosure relates to compositions and methods for reducing the risk of developing a lung cancer, colorectal cancer, or metastatic breast cancer in a subject, and methods of treating the same, comprising identifying a subject who has one or more risk factors for lung, colorectal or metastatic breast cancer and carries IL-1 single nucleotide polymorphisms (SNPs) associated with high levels of inflammation.

The disclosure relates to compositions and methods for reducing the risk of developing a lung cancer, colorectal cancer, or metastatic breast cancer in a subject, and methods of treating the same, comprising identifying a subject who has one or more risk factors for lung, colorectal or metastatic breast cancer and carries IL-1 single nucleotide polymorphisms (SNPs) associated with high levels of inflammation.

The disclosed subject matter relates to the construction and use of novel proteomics-based descriptor sets for analyzing high throughput proteomics derived pathogen-host interactome information and the use of these descriptor sets for identifying substances and substance combinations that have utility for treating and or preventing infections and diseases caused by a broad range of pathogens of diverse origins.

The disclosed subject matter relates to the construction and use of novel proteomics-based descriptor sets for analyzing high throughput proteomics derived pathogen-host interactome information and the use of these descriptor sets for identifying substances and substance combinations that have utility for treating and or preventing infections and diseases caused by a broad range of pathogens of diverse origins.

The present disclosure relates to an effect of inhibiting cancer metastasis by treatment of chlorphenesin and hydroxychloroquine alone or in combination. Chlorphenesin or hydroxychloroquine has the effect of inhibiting the metastasis and invasion of cancer cells. In particular, since it was identified that a combination thereof has a synergistic action, it is possible to effectively prevent or treat cancer metastasis by administering chlorphenesin and hydroxychloroquine respectively or in combination thereof.

The present disclosure relates to an effect of inhibiting cancer metastasis by treatment of chlorphenesin and hydroxychloroquine alone or in combination. Chlorphenesin or hydroxychloroquine has the effect of inhibiting the metastasis and invasion of cancer cells. In particular, since it was identified that a combination thereof has a synergistic action, it is possible to effectively prevent or treat cancer metastasis by administering chlorphenesin and hydroxychloroquine respectively or in combination thereof.

The present invention relates to the delivery of therapeutic agents into interstitial fluid and designed to substitute other forms of parenteral administration of fluid and medications when it is appropriate. The invention features an expandable reservoir made from mesh and a stylet guided catheter. The innovation of proposed catheter comprises to a catheter for administration of fluid and medications and a mechanism that safely secures the catheter inside the reservoir in order to prevent it from accidental dislodging. One of the ways to secure catheter is self-inflated balloon on its proximal end of the catheter.

The present invention relates to the delivery of therapeutic agents into interstitial fluid and designed to substitute other forms of parenteral administration of fluid and medications when it is appropriate. The invention features an expandable reservoir made from mesh and a stylet guided catheter. The innovation of proposed catheter comprises to a catheter for administration of fluid and medications and a mechanism that safely secures the catheter inside the reservoir in order to prevent it from accidental dislodging. One of the ways to secure catheter is self-inflated balloon on its proximal end of the catheter.

Ophthalmic formulations for acute and transient treatment of night vision disturbance syndrome (NVD) are presented. Preferred formulations comprise carbachol at very low concentrations that were demonstrated to unexpectedly provide an acute and transient therapeutic effect for a desirable magnitude and period of time.