The present disclosure relates to methods, compositions and apparatus for monitoring and improving oral health by utilizing information about nitric oxide levels in an individual's oral cavity. In an embodiment, the disclosure provides methods and apparatus for monitoring nitric oxide metabolites in saliva; this information may be utilized as it relates to improving oral health, i.e. monitoring and improving oral hygiene and increasing the consumption of nitric oxide-potent foods. In an embodiment, methods for improving oral health in a subject comprising, use of an oral cleanser by an individual, wherein the oral cleanser comprises a potassium nitrate source; and use of a saliva test strip for measuring nitrite and nitrogen oxides in the oral cavity of the individual are provided. In an embodiment, a novel nitrate-rich gum composition is provided.

The present technology relates generally to devices for acne treatment, as well as methods for preparing the devices and methods of treatment using the devices. Suitably, the devices comprise a hydrocolloid dressing and an active agent, wherein the amount of the active agent does not reduce the absorption properties of the hydrocolloid dressing. In exemplary embodiments, the active agent is salicylic acid, benzoyl peroxide or sulfur.

The present technology relates generally to devices for acne treatment, as well as methods for preparing the devices and methods of treatment using the devices. Suitably, the devices comprise a hydrocolloid dressing and an active agent, wherein the amount of the active agent does not reduce the absorption properties of the hydrocolloid dressing. In exemplary embodiments, the active agent is salicylic acid, benzoyl peroxide or sulfur.

A composition for the treatment of acne. The composition works without drying out the skin and exacerbating the cycle of acne, while promoting healing and reducing inflammation. The composition includes a cannabidiol, terpenoids, an antimicrobial, a soothing agent, a healing agent, or an anti-inflammatory agent, a healthy skin promoter, an antioxidant, and a mild, naturally derived antimicrobial agent. The composition may also include emulsifiers, humectants, preservatives, chelating agents, stabilizers, colorants, and fragrances. The composition may also include oils and fatty acids such as medium chain triglycerides (caprylic/capric triglyceride), Cannabis Sativa (hemp seed) oil, and Nigella Sativa (black cumin) seed oil.

A composition for the treatment of acne. The composition works without drying out the skin and exacerbating the cycle of acne, while promoting healing and reducing inflammation. The composition includes a cannabidiol, terpenoids, an antimicrobial, a soothing agent, a healing agent, or an anti-inflammatory agent, a healthy skin promoter, an antioxidant, and a mild, naturally derived antimicrobial agent. The composition may also include emulsifiers, humectants, preservatives, chelating agents, stabilizers, colorants, and fragrances. The composition may also include oils and fatty acids such as medium chain triglycerides (caprylic/capric triglyceride), Cannabis Sativa (hemp seed) oil, and Nigella Sativa (black cumin) seed oil.

The present invention relates to the discovery that etanercept reduces the rate of resistance to intravenous gamma globulin (IVIG) in subjects with acute Kawasaki disease (KD). In certain embodiments, the co-administration of etanercept and IVIG more effectively treats acute KD in subjects older than 12 months than IVIG alone. In other embodiments, the co-administration of etanercept and IVIG ameliorates coronary artery dilation in high risk subjects.

The present invention relates to the discovery that etanercept reduces the rate of resistance to intravenous gamma globulin (IVIG) in subjects with acute Kawasaki disease (KD). In certain embodiments, the co-administration of etanercept and IVIG more effectively treats acute KD in subjects older than 12 months than IVIG alone. In other embodiments, the co-administration of etanercept and IVIG ameliorates coronary artery dilation in high risk subjects.

Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.

Compositions for transdermal delivery of an active agent and methods for using such compositions are described herein.