The application provides a composition comprising cannadibiol, a fatty acid component comprising a balanced amount of omega-3 and omega-6 fatty acids, and a sterol and optionally a vitamin E compound. The composition has been shown to be well tolerated and supportive when administered to subjects suffering from or at risk of developing a skin disorder and/or an inflammatory condition, such as atopic dermatitis. Also disclosed are methods of supporting the immune system and skin health of a subject involving administration of the compositions.

The application provides a composition comprising cannadibiol, a fatty acid component comprising a balanced amount of omega-3 and omega-6 fatty acids, and a sterol and optionally a vitamin E compound. The composition has been shown to be well tolerated and supportive when administered to subjects suffering from or at risk of developing a skin disorder and/or an inflammatory condition, such as atopic dermatitis. Also disclosed are methods of supporting the immune system and skin health of a subject involving administration of the compositions.

Methods for treating ovarian cancer comprising: administering to a patient and effective amount of a cannabis extract comprising CBD, wherein preferably, the cannabis extract is administered via a mucosal formulation.

Methods for treating ovarian cancer comprising: administering to a patient and effective amount of a cannabis extract comprising CBD, wherein preferably, the cannabis extract is administered via a mucosal formulation.

A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD), wherein the composition is preferably administered in a mucosal form, such as intravaginally.

A method for treating a noncancerous gynecological disorder comprising: administering to a patient and effective amount of composition comprising a cannabis extract comprising cannabidiol (CBD), wherein the composition is preferably administered in a mucosal form, such as intravaginally.

The present invention provides a cell culture having a cartilage-like tissue forming property, including a cell population in which the expression intensity of at least one cell surface marker selected from the group consisting of CD166, CD165, CD99, GD2, STRO-1, CD108, CD164, CD6, CD106, and CD107b is not higher than the threshold for each cell surface marker, and/or, the expression intensity of at least one cell surface marker selected from the group consisting of CD26, CD73, CD105, CD44, CD120a, CD201, EGFR, CD146, CD140a, and CD90 is not lower than the threshold for each cell surface marker.

Provided is a bead for use in food or a beverage, the bead comprising: a core comprising: a continuous phase comprising: a lipophilic carrier, and a wax; a dispersed phase comprising: one or more particles, wherein each particle comprises: a first active ingredient, and a first polymer, and a first shell at least substantially surrounding the core.

Provided is a bead for use in food or a beverage, the bead comprising: a core comprising: a continuous phase comprising: a lipophilic carrier, and a wax; a dispersed phase comprising: one or more particles, wherein each particle comprises: a first active ingredient, and a first polymer, and a first shell at least substantially surrounding the core.

Disclosed are a means which enables simple and rapid detection of the presence or absence, and of the degree, of homologous recombination activity in an individual, and a means which is useful for detection and treatment of homologous recombination-restored cancer for which no treatment means is available at present. The nucleic acid construct of the present invention comprises: (1) a promoter region; (2) a mutant gene sequence containing a cleavage site in a gene sequence encoding a protein; and (3) a base sequence composed of a first homologous region and a second homologous region, the base sequence being capable of replacing, by homologous recombination, a partial region in the mutant gene sequence of (2), the partial region containing the cleavage site. The nucleic acid construct of the present invention can be used as a measurement reagent or kit for homologous recombination activity, a diagnostic agent for homologous recombination-deficient cancer, a therapeutic agent for homologous recombination-restored cancer, or the like.